甾醇组成改变对酿酒酵母生长特性的影响。
Effect of altered sterol composition on growth characteristics of Saccharomyces cerevisiae.
作者信息
Thompson E D, Parks L W
出版信息
J Bacteriol. 1974 Nov;120(2):779-84. doi: 10.1128/jb.120.2.779-784.1974.
Abstract
The function of sterols in mitochondrial structures of yeast was examined. Sterol mutant strains were employed to examine the effects of altered sterolic content on optimal and permissive growth temperatures in respiring and fermenting cultures. Although fermentative growth was unaffected by sterol composition, a definite decrease in both the optimal and the permissive growth temperatures of respiring cultures was observed when ergosterol was replaced by Delta(8(9), 22)-ergostadiene-3beta-ol. In vitro studies showed a similar decrease in membrane phase transition temperatures of the mitochondrial enzyme S-adenosylmethionine: Delta(24)-sterol methyltransferase in the mutant strains. Increased sterol and methyltransferase levels were detected in strains incapable of synthesizing ergosterol. A possible control function governing sterol synthesis is proposed for ergosterol.
摘要
研究了酵母线粒体结构中甾醇的功能。使用甾醇突变菌株来检测甾醇含量改变对呼吸和发酵培养物中最佳生长温度和允许生长温度的影响。尽管发酵生长不受甾醇组成的影响，但当麦角甾醇被Δ(8(9),22)-麦角甾二烯-3β-醇取代时，观察到呼吸培养物的最佳生长温度和允许生长温度均明显降低。体外研究表明，突变菌株中线粒体酶S-腺苷甲硫氨酸：Δ(24)-甾醇甲基转移酶的膜相变温度也有类似降低。在无法合成麦角甾醇的菌株中检测到甾醇和甲基转移酶水平升高。提出了麦角甾醇对甾醇合成可能的控制作用。
相似文献
1
Effect of altered sterol composition on growth characteristics of Saccharomyces cerevisiae.甾醇组成改变对酿酒酵母生长特性的影响。
J Bacteriol. 1974 Nov;120(2):779-84. doi: 10.1128/jb.120.2.779-784.1974.
2
The effect of altered sterol composition on cytochrome oxidase and S-adenosylmethionine: delta 24 sterol methyltransferase enzymes of yeast mitochondria.甾醇组成改变对酵母线粒体细胞色素氧化酶和S-腺苷甲硫氨酸：δ24甾醇甲基转移酶的影响。
Biochem Biophys Res Commun. 1974 Apr 23;57(4):1207-13. doi: 10.1016/0006-291x(74)90825-0.
3
Effects of sterol alterations on nystatin sensitivity in Saccharomyces cerevisiae.固醇改变对酿酒酵母制霉菌素敏感性的影响。
Microbios. 1989;59(239):101-11.
4
Yeast sterol esters and their relationship to the growth of yeast.酵母甾醇酯及其与酵母生长的关系。
J Bacteriol. 1975 Nov;124(2):606-12. doi: 10.1128/jb.124.2.606-612.1975.
5
[Sterol composition in yeast strains sensitive and resistant to nystatin].[对制霉菌素敏感和耐药的酵母菌株中的甾醇组成]
Prikl Biokhim Mikrobiol. 1985 Sep-Oct;21(5):631-3.
6
Sterol composition of a delta 5,7-sterol-rich strain of Saccharomyces cerevisiae during batch growth.酿酒酵母富含Δ5,7-甾醇菌株在分批培养期间的甾醇组成
Folia Microbiol (Praha). 1988;33(5):377-85. doi: 10.1007/BF02925848.
7
Sterol methylation in Saccharomyces cerevisiae.酿酒酵母中的甾醇甲基化
J Bacteriol. 1984 Feb;157(2):475-83. doi: 10.1128/jb.157.2.475-483.1984.
8
Potassium translocation in yeast mitochondria and its relationship to ergostrol biosynthesis.酵母线粒体中的钾离子转运及其与麦角固醇生物合成的关系。
J Bacteriol. 1975 May;122(2):606-9. doi: 10.1128/jb.122.2.606-609.1975.
9
Rate-limiting steps in the Saccharomyces cerevisiae ergosterol pathway: towards improved ergosta-5,7-dien-3β-ol accumulation by metabolic engineering.酿酒酵母麦角固醇途径中的限速步骤：通过代谢工程提高麦角甾-5,7-二烯-3β-醇的积累。
World J Microbiol Biotechnol. 2018 Mar 28;34(4):55. doi: 10.1007/s11274-018-2440-9.
10
Sterol control of the phosphatidylethanolamine-phosphatidylcholine conversion in the yeast mutant GL7.酵母突变体GL7中磷脂酰乙醇胺-磷脂酰胆碱转化的固醇调控
Proc Natl Acad Sci U S A. 1985 Sep;82(17):5715-9. doi: 10.1073/pnas.82.17.5715.
引用本文的文献
1
Inhibitors of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Decrease the Growth, Ergosterol Synthesis and Generation of Mutants in and .3-羟基-3-甲基戊二酰辅酶 A 还原酶抑制剂降低 和 中的生长、麦角固醇合成和突变体的产生。
Int J Mol Sci. 2023 Nov 28;24(23):16868. doi: 10.3390/ijms242316868.
2
Isolation of sterol mutants inChlamydomonas reinhardi: Chromatographic analyses.莱茵衣藻中固醇突变体的分离：色谱分析
Lipids. 1978 Aug;13(8):533-9. doi: 10.1007/BF02533592.
3
Use of nonionic surfactants for improvement of terpene production in Saccharomyces cerevisiae.使用非离子表面活性剂提高酿酒酵母中萜烯的产量。
Appl Environ Microbiol. 2014 Nov;80(21):6685-93. doi: 10.1128/AEM.02155-14. Epub 2014 Aug 22.
4
Aspects of sterol metabolism in the yeast Saccharomyces cerevisiae and in Phytophthora.酿酒酵母和疫霉中甾醇代谢的相关方面。
Lipids. 1982 Mar;17(3):187-96. doi: 10.1007/BF02535102.
5
Corresponding changes in kynurenine hydroxylase activity, membrane fluidity, and sterol composition in Saccharomyces cerevisiae mitochondria.酿酒酵母线粒体中犬尿氨酸羟化酶活性、膜流动性和甾醇组成的相应变化。
J Bacteriol. 1981 Mar;145(3):1325-33. doi: 10.1128/jb.145.3.1325-1333.1981.
6
Effect of altered sterol composition on the osmotic behavior of sphaeroplasts and mitochondria of Saccharomyces cerevisiae.甾醇组成改变对酿酒酵母原生质球和线粒体渗透行为的影响。
Lipids. 1982 Sep;17(9):662-5. doi: 10.1007/BF02535375.
7
Sterol methylation in Saccharomyces cerevisiae.酿酒酵母中的甾醇甲基化
J Bacteriol. 1984 Feb;157(2):475-83. doi: 10.1128/jb.157.2.475-483.1984.
8
Requirement for a second sterol biosynthetic mutation for viability of a sterol C-14 demethylation defect in Saccharomyces cerevisiae.酿酒酵母中甾醇C-14去甲基化缺陷的生存能力对第二种甾醇生物合成突变的需求。
J Bacteriol. 1983 Jul;155(1):64-8. doi: 10.1128/jb.155.1.64-68.1983.
9
Kinetics of delta 5,7-sterol accumulation during growth of Saccharomyces cerevisiae.酿酒酵母生长过程中δ5,7-甾醇积累的动力学
Folia Microbiol (Praha). 1987;32(1):13-23. doi: 10.1007/BF02877253.
10
Azole susceptibility and hyphal formation in a cytochrome P-450-deficient mutant of Candida albicans.白色念珠菌细胞色素P-450缺陷型突变体中的唑敏感性及菌丝形成
Antimicrob Agents Chemother. 1990 May;34(5):831-6. doi: 10.1128/AAC.34.5.831.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Mechanism of protection by sterols against polyene antibiotics.固醇类物质对抗多烯抗生素的保护机制。
J Bacteriol. 1960 Aug;80(2):200-6. doi: 10.1128/jb.80.2.200-206.1960.
3
Synthesis of lipids in resting cells of Saccharomyces cerevisiae.酿酒酵母静止细胞中脂质的合成。
J Bacteriol. 1955 Jun;69(6):620-7. doi: 10.1128/jb.69.6.620-627.1955.
4
TRANSMETHYLATION PRODUCTS AS INTERMEDIATES IN ERGOSTEROL BIOSYNTHESIS IN YEAST.作为酵母中麦角固醇生物合成中间体的转甲基化产物
Biochim Biophys Acta. 1965 Apr 5;98:394-401. doi: 10.1016/0005-2760(65)90132-3.
5
A relationship between ergosterol and respiratory competency in yeast.酵母中麦角固醇与呼吸能力之间的关系。
J Cell Comp Physiol. 1963 Feb;61:61-5. doi: 10.1002/jcp.1030610107.
6
Some factors affecting sterol formation in Saccharomyces cerevisiae.一些影响酿酒酵母中甾醇形成的因素。
J Bacteriol. 1962 May;83(5):1042-6. doi: 10.1128/jb.83.5.1042-1046.1962.
7
Effect of temperature on sterol metabolism in yeast.温度对酵母中甾醇代谢的影响。
J Cell Comp Physiol. 1962 Apr;59:107-10. doi: 10.1002/jcp.1030590203.
8
Studies on ergosterol production by yeasts.酵母麦角固醇生成的研究。
Appl Microbiol. 1954 Nov;2(6):371-9. doi: 10.1128/am.2.6.371-379.1954.
9
A genetic analysis of resistance to nystatin in Saccharomyces cerevisiae.酿酒酵母对制霉菌素抗性的遗传分析。
Genet Res. 1967 Apr;9(2):179-93. doi: 10.1017/s0016672300010478.
10
Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates.酵母中麦角固醇生物合成的研究。甲基化中间体的形成。
J Biol Chem. 1967 Jan 25;242(2):222-7.
Zotero 插件