酵母甾醇酯及其与酵母生长的关系。
Yeast sterol esters and their relationship to the growth of yeast.
作者信息
Bailey R B, Parks L W
出版信息
J Bacteriol. 1975 Nov;124(2):606-12. doi: 10.1128/jb.124.2.606-612.1975.
Abstract
Variation in the percentage of sterols esterified to long-chain fatty acids during cellular growth has been examined. Under all conditions, a constant percentage of sterol esters was maintained during exponential growth. This maintenance level was found to vary with different growth conditions. A sharp increase in the rate of esterification was observed upon entry of the culture into the stationary growth phase. The minor cellular sterol components were found to accumulate after this period of rapid sterol ester synthesis, with a relative decrease in the size of the ergosterol pool. Evidence is presented that sterol esters of ergosterol precursors are unable to be metabolized to ergosterol. Once esterified, the fatty acids do not appear to be scavenged during starvation conditions.
摘要
在细胞生长过程中，已对酯化到长链脂肪酸的甾醇百分比变化进行了研究。在所有条件下，指数生长期间甾醇酯的百分比保持恒定。发现这种维持水平随不同的生长条件而变化。当培养物进入稳定生长阶段时，观察到酯化速率急剧增加。在这段甾醇酯快速合成期之后，发现细胞中的次要甾醇成分会积累，麦角甾醇池的大小相对减小。有证据表明，麦角甾醇前体的甾醇酯无法代谢为麦角甾醇。一旦酯化，脂肪酸在饥饿条件下似乎不会被清除。
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