Aetiology of duodenal ulcer: an investigation into the buffering action and effect on pepsin of bran and unrefined carbohydrate foods.

It is unlikely that any possible protective action of wheat or rice bran or certain unrefined grains against peptic ulceration is due to any acid or pepsin lowering effect. Although these substances contain significant amounts of buffer, they also act as antral stimulants resulting in increased acid output. They also have no inhibitory effect on pepsin activity.