地西泮与其他传统药物治疗破伤风的对比临床试验。
Comparative clinical trial of diazepam with other conventional drugs in tetanus.
作者信息
Vassa N T, Doshi H V, Yajnik V H, Shah S S, Joshi K R, Patel S H
出版信息
Postgrad Med J. 1974 Dec;50(590):755-8. doi: 10.1136/pgmj.50.590.755.
Results of therapeutic trial of diazepam in tetanus are presented. The trial included 200 cases of tetanus—167 non-neonates and thirty-three neonates. The patients were divided into two groups and were matched as regards age, sex and severity of the disease. The cases of group I received standard treatment while the cases of group II received diazepam in addition. Over-all mortality in group I was 54% and in group II, 26%. The results were statistically significant in non-neonates and in severe degree of tetanus. The drug was well tolerated and side effects were not observed.
本文展示了地西泮治疗破伤风的试验结果。该试验纳入了200例破伤风患者，其中167例为非新生儿患者，33例为新生儿患者。患者被分为两组，并在年龄、性别和疾病严重程度方面进行了匹配。第一组患者接受标准治疗，而第二组患者在此基础上还接受了地西泮治疗。第一组的总体死亡率为54%，第二组为26%。在非新生儿患者和重度破伤风患者中，结果具有统计学意义。该药物耐受性良好，未观察到副作用。
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