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破伤风在埃塞俄比亚:揭示一种完全可通过疫苗预防的疾病的肆虐。

Tetanus in Ethiopia: unveiling the blight of an entirely vaccine-preventable disease.

机构信息

Anaesthetics, Pain Medicine and Intensive Care, Chelsea and Westminster Hospital, Imperial College London, 369 Fulham Road, London SW10 9NH, UK.

出版信息

Curr Neurol Neurosci Rep. 2012 Dec;12(6):655-65. doi: 10.1007/s11910-012-0314-3.

Abstract

Today, tetanus exacts its toll only in resource-poor countries like Ethiopia. Agrarian rural life with limited vaccine typifies tetanus risk in Ethiopia where current tetanus control trends on expanding infant immunization and eliminating highly prevalent maternal and neonatal tetanus (MNT). Protection by infant tetanus immunization primers disappears within an average of 3 years, if not followed by boosters. Second-year of life, school-based, and universal 10-yearly tetanus immunizations need to be supplemented. Facility-based reviews in Ethiopia reveal a continued burden of tetanus at tertiary-level hospitals where ICU care is suboptimal. Quality of medical care for tetanus is low - reflected by high case-fatality-rates. Opportunities at primary-health-care-units (antenatal-care, family planning, abortion, wound-care, tetanus-survivors) need to be fully-utilized to expand tetanus immunization. Prompt wound-care with post-exposure prophylaxis and proper footwear must be promoted. Standard ICU care needs to exist. Realization of cold-chain-flexible, needle-less and mono-dose vaccine programs allow avoiding boosters, vaccine-refrigeration, and improve compliance.

摘要

今天,破伤风仅在埃塞俄比亚等资源匮乏的国家造成影响。在埃塞俄比亚,农业农村生活中疫苗种类有限,破伤风风险较高,目前破伤风控制趋势是扩大婴儿免疫接种和消除高流行的孕产妇和新生儿破伤风(MNT)。如果不进行加强针接种,婴儿破伤风免疫接种的初级免疫保护作用平均在 3 年内就会消失。第二年的生命、基于学校的和普遍的 10 年破伤风免疫接种需要补充。埃塞俄比亚医疗机构的审查显示,三级医院的破伤风负担仍然很重,重症监护治疗并不理想。破伤风的医疗质量较低-反映在高病死率上。在初级保健单位(产前保健、计划生育、堕胎、伤口护理、破伤风幸存者)有机会充分利用扩大破伤风免疫接种。必须推广及时的伤口护理和接触后预防以及合适的鞋子。必须提供标准的重症监护治疗。实现冷链灵活、无针和单剂量疫苗计划可以避免加强针、疫苗冷藏和提高接种率。

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