化学性交感神经切除小鼠的细胞免疫反应抑制
Suppression of cellular immune response in chemically sympathectomized mice.
作者信息
Kasahara K, Tanaka S, Yamamuro T, Kasahara A, Hamashima Y
出版信息
Res Commun Chem Pathol Pharmacol. 1979 May;24(2):307-12.
Delayed-type hypersensitivity to methylated bovine serum albumin (MBSA), as induced by 6-hydroxydopamine (6-OHDA) was studied in chemically sympathectomized mice. Footpad reaction at 48 h after challenge injection of MBSA was suppressed with doses ranging from 10--300 mg/kg. 6-OHDA was neither cytotoxic to peritoneal macrophages nor was the function of immunoglobulin mediated phagocytosis suppressed. Thus, the suppression of delayed-type hypersensitivity may be attributed to interference with T-cell function.
在化学性交感神经切除的小鼠中，研究了由6-羟基多巴胺（6-OHDA）诱导的对甲基化牛血清白蛋白（MBSA）的迟发型超敏反应。在注射MBSA激发后48小时的足垫反应，在剂量为10 - 300mg/kg范围内受到抑制。6-OHDA对腹腔巨噬细胞既无细胞毒性，也不抑制免疫球蛋白介导的吞噬功能。因此，迟发型超敏反应的抑制可能归因于对T细胞功能的干扰。
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