Hejtmancik M, Williams B J
Res Commun Chem Pathol Pharmacol. 1979 May;24(2):367-76.
Neonatal lead exposure produces an enhanced susceptibility of the adult rat heart to the arrhythmogenic effects of norepinephrine. The present study examines the relationship of time and level of exposure to the extent of cardiac abnormality produced. The results indicate that the level of lead exposure required to produce norepinephrine cardiotoxicity without overt growth retardation is quite narrow, and lead must be present during the first ten days of life to cause these effects on the heart. A critical concentration of lead achieved during the early time period after birth appears necessary for the production of this cardiac abnormality, suggesting that lead interferes with neonatal cardiac and/or autonomic development.
新生儿铅暴露会使成年大鼠心脏对去甲肾上腺素的致心律失常作用的易感性增强。本研究探讨了暴露时间和暴露水平与所产生的心脏异常程度之间的关系。结果表明，在不出现明显生长迟缓的情况下产生去甲肾上腺素心脏毒性所需的铅暴露水平范围很窄，并且铅必须在出生后的前十天存在才能对心脏产生这些影响。出生后早期达到的临界铅浓度似乎是产生这种心脏异常所必需的，这表明铅会干扰新生儿心脏和/或自主神经系统的发育。
