6-氮杂尿苷-5'-磷酸：独特的分子结构与作用机制。 - Suppr | 超能文献

6-Azauridine-5'-phosphoric acid: unusual molecular structure and functional mechanism.

作者信息

Saenger W, Suck D

出版信息

Nature. 1973 Apr 27;242(5400):610-2. doi: 10.1038/242610a0.

DOI:10.1038/242610a0

Abstract

摘要

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。

相似文献

1

6-Azauridine-5'-phosphoric acid: unusual molecular structure and functional mechanism.6-氮杂尿苷-5'-磷酸：独特的分子结构与作用机制。

Nature. 1973 Apr 27;242(5400):610-2. doi: 10.1038/242610a0.

2

Inhibition of orotidine-5'-phosphate decarboxylase by 1-(5'-phospho-beta-d-ribofuranosyl)barbituric acid, 6-azauridine 5'-phosphate, and uridine 5'-phosphate.1-(5'-磷酸-β-D-呋喃核糖基)巴比妥酸、6-氮杂尿苷5'-磷酸和尿苷5'-磷酸对乳清苷-5'-磷酸脱羧酶的抑制作用

Biochemistry. 1980 Oct 28;19(22):4993-9. doi: 10.1021/bi00563a010.

3

Polymer-linked 6-azauridine 5'-monophosphate, a resin of high bioaffinity to orotidine-5'-phosphate decarboxylase.聚合物连接的6-氮杂尿苷5'-单磷酸，一种对乳清苷-5'-磷酸脱羧酶具有高生物亲和力的树脂。

J Med Chem. 1979 Dec;22(12):1545-7. doi: 10.1021/jm00198a023.

4

Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase.6-氰基尿苷 5′-单磷酸催化的鸟苷酸 5′-单磷酸脱羧酶的化学模型及其对转化的机制意义。

Chem Commun (Camb). 2010 Jul 14;46(26):4821-3. doi: 10.1039/c001865a. Epub 2010 May 25.

5

Rapid conversion of newly-synthesized orotate to uridine-5-monophosphate by rat liver cytosolic enzymes.大鼠肝细胞溶质酶将新合成的乳清酸盐快速转化为5-磷酸尿苷。

FEBS Lett. 1983 Mar 7;153(1):1-5. doi: 10.1016/0014-5793(83)80107-0.

6

Pyrimidine biosynthesis.嘧啶生物合成

Am J Clin Nutr. 1979 Jun;32(6):1290-7. doi: 10.1093/ajcn/32.6.1290.

7

Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase.化学模型及其对由乳清苷5'-单磷酸脱羧酶催化的6-氰基尿苷5'-单磷酸转化的机理影响。

Nucleic Acids Symp Ser (Oxf). 2008(52):297-8. doi: 10.1093/nass/nrn150.

8

Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate.乳清苷5'-单磷酸脱羧酶的产物氘同位素效应：存在短寿命碳负离子中间体的证据。

J Am Chem Soc. 2007 Oct 31;129(43):12946-7. doi: 10.1021/ja076222f. Epub 2007 Oct 5.

9

Uracil metabolism--UMP synthesis from orotic acid or uridine and conversion of uracil to beta-alanine: enzymes and cDNAs.尿嘧啶代谢——从乳清酸或尿苷合成UMP以及尿嘧啶转化为β-丙氨酸：酶和cDNA

Prog Nucleic Acid Res Mol Biol. 1996;53:1-78. doi: 10.1016/s0079-6603(08)60142-7.

10

Does the bifunctional uridylate synthase channel orotidine 5'-phosphate? Kinetics of orotate phosphoribosyltransferase and orotidylate decarboxylase activities fit a noninteracting sites model.双功能尿苷酸合酶是否催化乳清酸生成5'-磷酸乳清酸？乳清酸磷酸核糖基转移酶和乳清酸脱羧酶活性的动力学符合非相互作用位点模型。

Biochemistry. 1987 Jun 16;26(12):3378-84. doi: 10.1021/bi00386a020.

引用本文的文献

1

The properties of ATP-analogs in initiation of RNA synthesis catalyzed by RNA polymerase from E coli.ATP类似物在大肠杆菌RNA聚合酶催化的RNA合成起始过程中的特性。

Nucleic Acids Res. 1981 May 25;9(10):2397-410. doi: 10.1093/nar/9.10.2397.

2

Theoretical studies of the conformational properties of ribavirin.利巴韦林构象性质的理论研究。

Proc Natl Acad Sci U S A. 1976 Dec;73(12):4257-60. doi: 10.1073/pnas.73.12.4257.