人IgM冷凝集素的轻链序列（可变区亚组氨基酸序列-κ轻链- N端）
Light chain sequences of human IgM cold agglutinins (variable-region subgroups amino-acid sequence-kappa light chain-N-terminal).
作者信息
Capra J D, Kehoe J M, Williams R C, Feizi T, Kunkel H G
出版信息
Proc Natl Acad Sci U S A. 1972 Jan;69(1):40-3. doi: 10.1073/pnas.69.1.40.
Abstract
The amino-terminal amino-acid sequence has been determined for the kappa light chains of nine IgM cold agglutinins with specificity for blood group-related carbohydrate antigens. Six of the nine sequences corresponded to the prototype VK(III) subgroup pattern, two to that of subgroup VK(II), and only one to the VK(I) subgroup. This distribution of kappa subgroups differs markedly from that of normal and myeloma proteins sequenced to date, where the VK(I) subgroup is more prevalent than either VK(II) or VK(III). Evidence is presented that supports the conclusion that the unusual subgroup distribution relates to the antibody property itself and not to some other attribute of these molecules.
摘要
已确定9种对血型相关碳水化合物抗原有特异性的IgM冷凝集素κ轻链的氨基末端氨基酸序列。9个序列中的6个与原型VK(III)亚组模式相对应，2个与VK(II)亚组相对应，只有1个与VK(I)亚组相对应。κ亚组的这种分布与迄今为止测序的正常和骨髓瘤蛋白的分布明显不同，在正常和骨髓瘤蛋白中，VK(I)亚组比VK(II)或VK(III)更为普遍。有证据支持这样的结论，即这种不寻常的亚组分布与抗体特性本身有关，而与这些分子的其他某些属性无关。
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Proc Natl Acad Sci U S A. 1972 Jan;69(1):40-3. doi: 10.1073/pnas.69.1.40.
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