Riesen W F, Majaniemi I, Huser H, Braun D G, Roelcke D
Scand J Immunol. 1978;8(2):145-8. doi: 10.1111/j.1365-3083.1978.tb00506.x.
The variable-region subgroup determined by amino acid sequence analysis of heavy and light chains of two monoclonal cold agglutinins with the new anti-Gd specificity is reported. Both proteins belong to the VHIII subgroup of heavy chains; one light chain falls into the V kappaI subgroup, the other has a blocked N-terminus which so far has not been observed in human kappa chains. The comparison of anti-Gd with anti-I/-i or anti-Pr cold agglutinins indicates that anti-Gd differs from other cold agglutinins with respect to variable-region subgroup. The data extend previous findings on the restriction of certain antibodies to distinct variable-region subgroups.
报道了通过对两种具有新型抗-Gd特异性的单克隆冷凝集素的重链和轻链进行氨基酸序列分析所确定的可变区亚组。两种蛋白均属于重链的VHIII亚组；一条轻链属于VκI亚组，另一条轻链的N端封闭，这在人κ链中尚未观察到。抗-Gd与抗-I/-i或抗-Pr冷凝集素的比较表明，抗-Gd在可变区亚组方面与其他冷凝集素不同。这些数据扩展了先前关于某些抗体局限于不同可变区亚组的发现。
