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慢性低补体血症增殖性肾小球肾炎患者血清中的C3灭活因子。

C3 inactivating factor in the serum of a patient with chronic hypocomplementaemic proliferative glomerulo-nephritis.

作者信息

Thompson R A

出版信息

Immunology. 1972 Jan;22(1):147-58.

PMID:4622449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1408205/
Abstract

The serum of a patient with proliferative glomerulo-nephritis and persistent hypocomplementaemia, with low C3 and high C4 levels, was found to cause electrophoretic conversion of C3 when mixed and incubated with normal serum. This activity was found to resist heat at 56° for 30 minutes, and to be due to a fraction of the patient's IgG with a high content of IgG. The effect of this fraction on normal human serum was to cause a decrease in the total haemolytic titre with considerable electrophoretic conversion of C3, while barely affecting functions ascribed to the action of the early complement components.

摘要

一名患有增殖性肾小球肾炎且持续低补体血症（C3低、C4高）的患者血清，在与正常血清混合并孵育时，被发现会导致C3发生电泳转化。该活性在56℃加热30分钟后仍能抵抗，且是由于患者IgG的一部分，其IgG含量较高。该部分对正常人血清的作用是导致总溶血效价降低，同时C3发生相当程度的电泳转化，而对早期补体成分作用所赋予的功能影响极小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/ff2c39fe7529/immunology00348-0157-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/a46525e5a404/immunology00348-0152-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/2bcd455b6a4e/immunology00348-0152-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/27581d16ff5f/immunology00348-0154-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/911e9b5b35e3/immunology00348-0154-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/083661846e57/immunology00348-0155-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/5104e50ddaa9/immunology00348-0157-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/ff2c39fe7529/immunology00348-0157-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/a46525e5a404/immunology00348-0152-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/2bcd455b6a4e/immunology00348-0152-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/27581d16ff5f/immunology00348-0154-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/911e9b5b35e3/immunology00348-0154-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/083661846e57/immunology00348-0155-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/5104e50ddaa9/immunology00348-0157-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d7/1408205/ff2c39fe7529/immunology00348-0157-b.jpg

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本文引用的文献

1
[Method permitting the combined study of the electrophoretic and the immunochemical properties of protein mixtures; application to blood serum].[蛋白质混合物电泳和免疫化学性质联合研究方法；应用于血清]
Biochim Biophys Acta. 1953 Jan;10(1):193-4. doi: 10.1016/0006-3002(53)90233-9.
2
Immune haemolysis in agar: demonstration of the protective action of antibodies.琼脂中的免疫溶血：抗体保护作用的证明
Immunology. 1967 Oct;13(4):411-20.
3
Complement inactivation by serum from patients with acute and hypocomplementemic chronic glomerulonephritis.
终末补体成分基因缺陷患者的复发性细菌性脑膜炎
Clin Exp Immunol. 1980 Apr;40(1):16-24.
4
Mechanism of action of the C4 nephritic factor. Deregulation of the classical pathway of C3 convertase.C4肾炎因子的作用机制。C3转化酶经典途径的失调。
J Exp Med. 1981 Jul 1;154(1):1-12. doi: 10.1084/jem.154.1.1.
5
Nephritic factor of the classical pathway of complement: immunoglobulin G autoantibody directed against the classical pathway C3 convetase enzyme.补体经典途径的肾炎因子：针对经典途径C3转化酶的免疫球蛋白G自身抗体。
J Clin Invest. 1980 Jun;65(6):1249-56. doi: 10.1172/jci109787.
6
The role of carbohydrate in the structure and function of nephritic factor.碳水化合物在肾炎因子结构与功能中的作用。
Clin Exp Immunol. 1981 Oct;46(1):120-9.
7
C3 nephritic factor and hypocomplementaemia in a clinically healthy individual.一名临床健康个体中的C3肾炎因子与低补体血症
Clin Exp Immunol. 1983 Oct;54(1):253-8.
8
Hypocomplementaemia due to a genetic deficiency of beta 1H globulin.由于β1H球蛋白基因缺陷导致的补体血症。
Clin Exp Immunol. 1981 Oct;46(1):110-9.
9
The quest for an intrinsic C3 activating factor in human glomerular disease.对人类肾小球疾病中一种内源性C3激活因子的探索。
Surv Immunol Res. 1982;1(2):191-8. doi: 10.1007/BF02918345.
10
IgG3 levels in patients with chronic membranoproliferative glomerulonephritis.慢性膜增生性肾小球肾炎患者的IgG3水平
Br Med J. 1972 Jan 29;1(5795):282-4. doi: 10.1136/bmj.1.5795.282.
急性和低补体血症性慢性肾小球肾炎患者血清对补体的灭活作用。
J Lab Clin Med. 1968 Aug;72(2):298-307.
4
Serial complement component alterations in acute glomerulonephritis and systemic lupus erythematosus.急性肾小球肾炎和系统性红斑狼疮中补体成分的系列变化
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J Exp Med. 1970 Apr 1;131(4):629-41. doi: 10.1084/jem.131.4.629.
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J Exp Med. 1970 Jun 1;131(6):1306-24. doi: 10.1084/jem.131.6.1306.
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Biologically active water-insoluble protein polymers. I. Their use for isolation of antigens and antibodies.生物活性水不溶性蛋白质聚合物。I. 其在抗原和抗体分离中的应用。
J Biol Chem. 1967 Apr 10;242(7):1651-9.
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Lancet. 1966 Dec 3;2(7475):1224-6. doi: 10.1016/s0140-6736(66)92305-1.