枯草芽孢杆菌烷基化敏感突变体的诱变剂稳定性
Mutagen stability of alkylation-sensitive mutants of Bacillus subtilis.
作者信息
Hill T, Prakash L, Strauss B
出版信息
J Bacteriol. 1972 Apr;110(1):47-55. doi: 10.1128/jb.110.1.47-55.1972.
Abstract
A series of mutations of Bacillus subtilis, conferring sensitivity to methyl methanesulfonate (MMS), were transferred by transformation to a suppressible his(-) stock. The introduction of certain sensitivity mutations prevented the ultraviolet- or MMS-induced, but not the spontaneous, reversion of his(-) to his(+). Not all sensitivity mutations led to this resistance to mutagenesis; a strain with altered deoxyribonucleic acid (DNA) polymerase activity behaved almost normally with respect to its mutagen response, as did an excision-defective, ultraviolet-sensitive strain used as a control. One of the mutagen-stable strains responded to mutagenesis with nitrosomethylguanidine; another appeared stable even to this mutagen. All mutagen-stable strains had DNA polymerase and DNA ligase activity.
摘要
一系列使枯草芽孢杆菌对甲磺酸甲酯（MMS）敏感的突变，通过转化转移到一个可抑制的组氨酸缺陷（his(-)）菌株中。引入某些敏感突变会阻止紫外线或MMS诱导的his(-)向his(+)的回复突变，但不会阻止自发回复突变。并非所有敏感突变都会导致这种对诱变的抗性；一个具有改变的脱氧核糖核酸（DNA）聚合酶活性的菌株在诱变反应方面表现几乎正常，用作对照的一个切除缺陷型、对紫外线敏感的菌株也是如此。其中一个诱变稳定菌株对亚硝基甲基胍诱变有反应；另一个甚至对这种诱变剂也表现稳定。所有诱变稳定菌株都具有DNA聚合酶和DNA连接酶活性。
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