Irsigler G B, de Villiers T, van der Veen G, van Gelder A
S Afr Med J. 1979 May 5;55(19):749-51.
Two obese patients with acute respiratory failure are described. Both required mechanical ventilation to reverse the respiratory acidosis. On recovery, the major abnormality was failure of ventilatory response to inhaled carbon dioxide. After oral progesterone (100 mg/day and 20 mg/day, respectively) the slope of the carbon dioxide response line increased from 0,02 to 1,14 I min-1 mmHg-1 and from 0,04 to 1,14 I min-1 mmHg-1, respectively. This was associated with sustained clinical remission in 1 patient.
描述了两名患有急性呼吸衰竭的肥胖患者。两人均需要机械通气来纠正呼吸性酸中毒。康复后，主要异常是对吸入二氧化碳的通气反应失败。分别给予口服孕酮（每日100毫克和每日20毫克）后，二氧化碳反应线的斜率分别从0.02增加到1.14升/分钟/毫米汞柱和从0.04增加到1.14升/分钟/毫米汞柱。这与1例患者的持续临床缓解相关。
