Silverstein D, Michlin B, Sobel H J, Lavietes M H
Respiration. 1983;44(6):460-5. doi: 10.1159/000194585.
An unusual patient with hypoxemia, hypercapnia, and right ventricular failure is presented. Minimal skeletal muscle weakness, although present, cannot explain hypercapnia. Muscle biopsy revealed diabetic microangiopathy. Carbon dioxide stimulation demonstrated a diminished hypercapnic ventilatory response. The patient benefited from progesterone therapy. In this unusual patient, mild muscular weakness, caused by diabetes, and central alveolar hypoventilation have acted in synergism to cause abnormal ventilation and right ventricular failure.
本文报告了一位患有低氧血症、高碳酸血症和右心室衰竭的特殊患者。尽管存在轻微的骨骼肌无力，但这并不能解释高碳酸血症的原因。肌肉活检显示有糖尿病微血管病变。二氧化碳刺激试验表明高碳酸血症通气反应减弱。该患者从孕酮治疗中获益。在这位特殊患者中，由糖尿病引起的轻度肌肉无力与中枢性肺泡通气不足协同作用，导致了异常通气和右心室衰竭。
