兔和仓鼠对聚肌胞苷酸的干扰素及造血集落抑制反应
Interferon and haemopoietic colony inhibitor responses to poly I-poly C in rabbits and hamsters.
作者信息
McNeill T A, Fleming W A, McCance D J
出版信息
Immunology. 1972 May;22(5):711-21.
Abstract
Intravenous or intraperitoneal inoculation of Poly I—Poly C into rabbits induced an inhibitor for rabbit bone marrow colony growth in the serum which associated with interferon after fractionation on Sephadex G-200. Inoculation of hamsters with Poly I—Poly C did not induce either inhibitor for hamster colonies or interferon. Other substances can cause colony inhibition besides interferon and these were detected in both normal rabbit and normal hamster serum. Colony inhibition shows some species specificity, but cross-inhibition of monkey and mouse colony growth was shown with rabbit inhibitor. It is suggested that the basic biological role of interferon may lie in the control of cellular differentiation.
摘要
给兔子静脉内或腹腔内接种聚肌胞苷酸（Poly I—Poly C）可在血清中诱导出一种抑制兔骨髓集落生长的物质，在Sephadex G - 200上分级分离后，该物质与干扰素相关。给仓鼠接种聚肌胞苷酸既不诱导仓鼠集落生长抑制物，也不诱导干扰素。除干扰素外，其他物质也可导致集落抑制，在正常兔血清和正常仓鼠血清中均检测到这些物质。集落抑制表现出一定的种属特异性，但兔抑制物对猴和小鼠集落生长有交叉抑制作用。有人提出，干扰素的基本生物学作用可能在于控制细胞分化。
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本文引用的文献
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Tissue specificity of interferon prepared in various tissue cultures.在各种组织培养物中制备的干扰素的组织特异性。
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Inducers of interferon inhibit the mitotic response of liver cells to partial hepatectomy.干扰素诱导剂可抑制肝细胞对部分肝切除的有丝分裂反应。
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