合成双链多聚核糖核苷酸对体外造血集落形成细胞的影响。
The effect of synthetic double-stranded polyribonucleotides on haemopoietic colony-forming cells in vitro.
作者信息
McNeill T A
出版信息
Immunology. 1971 Nov;21(5):741-50.
Abstract
Addition of low concentrations of the synthetic double-stranded polynucleotides Poly I—Poly C and Poly AU to stimulated cultures of normal mouse bone marrow increased the number of macrophage colonies in the cultures. Double strandedness of the polynucleotides was essential for activity and they were active without the α-globulin which was previously shown to be a necessary co-factor in colony potentiation by some antigens. The evidence suggested that polynucleotides acted at the cell surface to make colony forming cells more responsive to colony stimulating factor.
摘要
向正常小鼠骨髓的刺激培养物中添加低浓度的合成双链多核苷酸聚肌苷酸-聚胞苷酸（Poly I—Poly C）和聚腺苷酸-聚尿苷酸（Poly AU），可增加培养物中巨噬细胞集落的数量。多核苷酸的双链结构对其活性至关重要，并且它们在没有α球蛋白的情况下仍具有活性，而α球蛋白此前被证明是某些抗原增强集落形成的必要辅助因子。证据表明，多核苷酸作用于细胞表面，使集落形成细胞对集落刺激因子更敏感。
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本文引用的文献
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