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合成双链多聚核糖核苷酸对体内造血集落形成细胞的作用。

The effect of synthetic double-stranded polyribonucleotides on haemopoietic colony-forming cells in vivo.

作者信息

McNeill T A, Killen M

出版信息

Immunology. 1971 Nov;21(5):751-9.

Abstract

Intraperitoneal inoculation of 100 μg Poly I—Poly C resulted in an an eight-fold increase in spleen colony forming cells by the sixth day after inoculation. The same dose of Poly AU resulted in a negligible cellular response and no increase in the level of colony stimulating factor in the serum. The colony stimulating activity of serum after inoculation of Poly I—Poly C was increased, but assay of this increase in early sera was complicated by the presence of a colony inhibitor. Some properties of inhibitor-containing sera were investigated and consideration given to the possibility that the colony inhibitor is related to interferon.

摘要

腹腔内接种100微克聚肌胞苷酸,在接种后第6天脾脏集落形成细胞增加了8倍。相同剂量的聚腺苷尿苷酸引起的细胞反应可忽略不计,血清中集落刺激因子水平也未升高。接种聚肌胞苷酸后血清的集落刺激活性增强,但早期血清中这种活性增强的检测因存在集落抑制剂而变得复杂。对含抑制剂血清的一些特性进行了研究,并考虑了集落抑制剂与干扰素相关的可能性。

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