Manning D D, Jutila J W
J Exp Med. 1972 Jun 1;135(6):1316-33. doi: 10.1084/jem.135.6.1316.
Neonatal injection of mice with rabbit anti-micro antiserum has been shown to produce complete loss of direct and indirect plaque-forming responses to sheep erythrocytes as well as loss of serum IgM and severe depressions of all other serum immunoglobulins. Similar injection of anti-gamma1gamma2 or anti-gamma1 antibodies effects a loss of the indirect response but induces relatively minor alterations in serum Ig levels. Delaying initiation of anti-micro treatment until young adulthood results in a somewhat diminished effect on plaque-forming responses and serum Ig levels but triggers the release of high serum levels of an aberrant micro-bearing protein. Anti-micro suppression of genetically thymusless mice indicates that at least part of the target cells for suppression are bone marrow derived. A working hypothesis for the maturation of humoral antibody-producing cell lines as it relates to these data is discussed.
给新生小鼠注射兔抗微生物抗血清已显示会导致对绵羊红细胞的直接和间接噬斑形成反应完全丧失，同时血清IgM丧失，以及所有其他血清免疫球蛋白严重降低。类似地注射抗γ1γ2或抗γ1抗体则会导致间接反应丧失，但血清Ig水平的变化相对较小。将抗微生物治疗的开始时间推迟到成年早期，对噬斑形成反应和血清Ig水平的影响会有所减弱，但会引发血清中高浓度异常携带微生物的蛋白质的释放。对无胸腺基因小鼠的抗微生物抑制表明，至少部分被抑制的靶细胞是骨髓来源的。本文讨论了与这些数据相关的体液抗体产生细胞系成熟的一个可行假说。
