体外免疫反应。V. 用小鼠免疫球蛋白类特异性抗体对致敏小鼠脾细胞培养物中M、G和A斑块形成细胞反应的抑制作用。
Immune responses in vitro. V. Suppression of M, G, and A plaque-forming cell responses in cultures of primed mouse spleen cells by class-specific antibody to mouse immunoglobulins.
作者信息
Pierce C W, Solliday S M, Asofsky R
出版信息
J Exp Med. 1972 Mar 1;135(3):698-710. doi: 10.1084/jem.135.3.698.
Abstract
Suppression of Ig class-specific PFC responses by class-specific antibody to mouse immunoglobulin was studied in cultures of spleen cells from immunized mice. In contrast to cultures from normal mice where anti-micro suppressed responses in all Ig classes, anti-micro had progressively less suppressive effect on gamma(1) and gamma(2) responses in cultures from immunized mice with time after immunization. This was most pronounced at 10 days after immunization when anti-micro suppressed gammaM and gammaA responses, but had no or slight effect on gamma(1) or gamma(2) responses which were still suppressed with anti-gamma(1) and anti-gamma(2). These changes in precursor cell susceptibility to anti-micro were antigen specific.
摘要
在免疫小鼠的脾细胞培养物中，研究了针对小鼠免疫球蛋白的类特异性抗体对Ig类特异性PFC反应的抑制作用。与正常小鼠的培养物不同，在正常小鼠培养物中抗μ抑制所有Ig类别的反应，而在免疫小鼠的培养物中，随着免疫后时间的推移，抗μ对γ(1)和γ(2)反应的抑制作用逐渐减弱。这在免疫后10天时最为明显，此时抗μ抑制γM和γA反应，但对γ(1)或γ(2)反应没有或只有轻微影响，而γ(1)和γ(2)反应仍被抗γ(1)和抗γ(2)抑制。前体细胞对抗μ敏感性的这些变化是抗原特异性的。
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本文引用的文献
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Plaque Formation in Agar by Single Antibody-Producing Cells.琼脂中由单个抗体产生细胞形成的斑块。
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VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE.免疫应答过程中抗体亲和力的变化
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