Hawiger J, Marney S R, Colley D G, Des Prez R M
J Exp Med. 1972 Jul 1;136(1):68-80. doi: 10.1084/jem.136.1.68.
A new example of complement-mediated platelet injury has been described. Staphylococcal protein A (SPA) causes rabbit platelet injury as manifested by release of platelet 5-hydroxytryptamine (5HT). This reaction is complement-dependent and occurs over a very small range of SPA concentration, larger amounts being inhibitory. Complement fixation by SPA demonstrates the same narrow SPA concentration requirement whereas precipitation of IgG by SPA is roughly proportional to SPA concentration over a wide concentration range. The reaction can be separated into a sensitization step which requires SPA and plasma but not complement, and a release step which does require complement. Complement-mediated platelet damage induced by SPA is a new biologic property of this common component of the cell wall of pathogenic staphylococci which may contribute to the development of inflammatory and thromboembolic reactions complicating intravascular staphylococcal infection.
已描述了补体介导的血小板损伤的一个新例子。葡萄球菌蛋白A（SPA）可导致兔血小板损伤，表现为血小板5-羟色胺（5HT）的释放。该反应依赖补体，且在非常窄的SPA浓度范围内发生，更高浓度则具有抑制作用。SPA的补体固定表现出相同的窄SPA浓度要求，而SPA对IgG的沉淀在很宽的浓度范围内大致与SPA浓度成正比。该反应可分为一个致敏步骤和一个释放步骤，致敏步骤需要SPA和血浆但不需要补体，释放步骤则确实需要补体。SPA诱导的补体介导的血小板损伤是致病性葡萄球菌细胞壁这一常见成分的一种新生物学特性，可能有助于并发血管内葡萄球菌感染的炎症和血栓栓塞反应的发展。
