维拉帕米对甘油处理的犬心肌收缩力的影响。
Effects of verapamil on the contractile force in the glycerinated dog heart muscles.
作者信息
Maruyama Y, Ishide N, Okayama H, Ino-Oka E, Takishima T
出版信息
Tohoku J Exp Med. 1979 Jun;128(2):199-200. doi: 10.1620/tjem.128.199.
PMID:462479
Abstract
The effect of Ca-antagonist on the contractile apparatus was investigated in glycerinated cardiac papillary muscle preparations obtained from canine hearts. The results showed that maximal developed tension (P0) was enhanced significantly by 5 mg/liter of verapamil, and the augmentation of contractility was dependent on the concentrations of verapamil. As a conclusion, Ca-antagonist appeared to be a potentiating agent of the contractile force on the contractile apparatus.
摘要
在从犬心脏获取的甘油化心脏乳头肌标本中研究了钙拮抗剂对收缩装置的作用。结果显示，5毫克/升维拉帕米可显著增强最大舒张张力（P0），且收缩性的增强取决于维拉帕米的浓度。结论是，钙拮抗剂似乎是收缩装置收缩力的增强剂。
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