Maruyama Y, Bing R J, Sarma J S, Weishaar R
Jpn Heart J. 1978 Jul;19(4):513-21. doi: 10.1536/ihj.19.513.
The response of the contractile and the series elastic elements to ethanol was studied isometric contraction and quick release methods after measuring the passive length-tension relationship in glycerinated heart muscle fibers of rats at resting state. In rats consuming 30% ethanol for an average of 5 weeks, maximal developed tension (P0), the maximal rate of tension development (dp/dtmax) and Vmax were significantly depressed, the time to peak tension (t0) was not changed. As in fresh papillary muscle the modulus of elasticity of active glycerinated muscle increased in proportion to load. The stiffness of the series elastic element showed significant elevation in rats receiving ethanol. The passive stiffness in resting state revealed no significant difference between control and alcohol exposed rats. Therefore, increased stiffness of the series elastic element and diminished contractility are present following chronic alcohol consumption.
在测量大鼠甘油化心肌纤维静息状态下的被动长度-张力关系后，采用等长收缩和快速释放方法研究了收缩元件和串联弹性元件对乙醇的反应。在平均饮用30%乙醇5周的大鼠中，最大张力（P0）、最大张力发展速率（dp/dtmax）和Vmax显著降低，张力达到峰值的时间（t0）没有变化。与新鲜乳头肌一样，活性甘油化肌肉的弹性模量与负荷成正比增加。接受乙醇的大鼠串联弹性元件的刚度显著升高。对照组和暴露于乙醇的大鼠在静息状态下的被动刚度没有显著差异。因此，长期饮酒后会出现串联弹性元件刚度增加和收缩力减弱的情况。
