Stepan'ian L I, Shvemberger I N
Tsitologiia. 1979 Jun;21(6):711-6.
The study of rat testis seminoma by the method of clonal analysis and ectopic transplantations has shown that typical and anaplastic types are different stages of tumor progression in the course of which atypical and anaplastic features of the seminoma cell elements increase. It does not seem inconceivable that the spermacytic form, never encountered during our investigation of 400 tumors, may be an independent seminoma form incapable of transforming into a typical one. A spindle-cell form of seminoma has been described most frequently occurring during transplantation of a typical seminoma into testis and during cloning. The obtained evidence permits to consider the small dark cells of the seminoma as being cambial cells of the tumor which occur abundantly in growing tumors, and are absent in tumors with ceased proloferating. At later stages of the seminoma development, the small dark cells may be absent, their function being performed practically by all tumor cells. Acinar structures found in part of clones from lungs and in the majority of transplants from eye anterior chamber suggest a histogenetic relationship between the typical seminoma and embryocarcinoma, and thus enable us to regard the latter as the most differentiated variants of the seminoma.
通过克隆分析和异位移植方法对大鼠睾丸精原细胞瘤的研究表明，典型型和间变型是肿瘤进展的不同阶段，在此过程中精原细胞瘤细胞成分的非典型和间变特征会增加。在我们对400个肿瘤的研究中从未遇到过的精母细胞型，有可能是一种独立的、无法转化为典型型的精原细胞瘤类型，这并非不可思议。精原细胞瘤的梭形细胞型在典型精原细胞瘤移植到睾丸及克隆过程中最为常见。所获得的证据使我们能够将精原细胞瘤的小暗细胞视为肿瘤的生发细胞，这些细胞在生长中的肿瘤中大量存在，而在增殖停止的肿瘤中则不存在。在精原细胞瘤发展的后期，小暗细胞可能不存在，其功能实际上由所有肿瘤细胞执行。在部分肺克隆及大多数眼前房移植中发现的腺泡结构表明典型精原细胞瘤与胚胎癌之间存在组织发生学关系，因此使我们能够将后者视为精原细胞瘤最分化的变体。
