Folate antagonists. 2. 2,4-Diamino-6-((aralkyl and (heterocyclic)methyl)amino)quinazolines, a novel class of antimetabolites of interest in drug-resistant malaria and Chagas' disease.

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作者信息

Davoll J, Johnson A M, Davies H J, Bird O D, Clarke J, Elslager E F

出版信息

J Med Chem. 1972 Aug;15(8):812-26. doi: 10.1021/jm00278a007.

DOI:10.1021/jm00278a007

PMID:4625529

Abstract

摘要

相似文献

Folate antagonists. 2. 2,4-Diamino-6-((aralkyl and (heterocyclic)methyl)amino)quinazolines, a novel class of antimetabolites of interest in drug-resistant malaria and Chagas' disease.

J Med Chem. 1972 Aug;15(8):812-26. doi: 10.1021/jm00278a007.

Folate antagonists. 3. 2,4-Diamino-6-(heterocyclic)quinazolines, a novel class of antimetabolites with potent antimalarial and antibacterial activity.

J Med Chem. 1972 Aug;15(8):827-36. doi: 10.1021/jm00278a008.

Folate antagonists. 9. 2,4-Diamino-6-((aralkyl)alkylamino)quinazolines, a potent class of antimetabolites with prodigious antimalarial effects.

J Med Chem. 1972 Nov;15(11):1138-46. doi: 10.1021/jm00281a012.

Folate antagonists. 4. Antimalarial and antimetabolite effects of 2,4-diamino-6-((benzyl)amino)pyrido(2,3-d)-pyrimidines.叶酸拮抗剂。4. 2,4-二氨基-6-（苄基）氨基吡啶并[2,3-d]嘧啶的抗疟和抗代谢作用。

J Med Chem. 1972 Aug;15(8):837-9. doi: 10.1021/jm00278a009.

Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclid)thio-, sulfinyl-, and sulfonyl]quinazolines.

J Med Chem. 1978 Jul;21(7):639-43. doi: 10.1021/jm00205a009.

Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects.叶酸拮抗剂。13. 2,4 - 二氨基 - 6 - [（α,α,α - 三氟 - 间甲苯基）硫代]喹唑啉及相关的2,4 - 二氨基 - 6 - [（苯基和萘基）硫代]喹唑啉，一类具有非凡抗疟和抗菌作用的独特抗代谢物。

J Med Chem. 1978 Oct;21(10):1059-70. doi: 10.1021/jm00208a010.

Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity.

J Med Chem. 1979 Oct;22(10):1247-57. doi: 10.1021/jm00196a019.

Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines.

J Med Chem. 1983 Dec;26(12):1753-60. doi: 10.1021/jm00366a018.

Inhibition of mammalian dihydrofolate reductase by selected 2,4-diaminiquinazolines and related compounds.某些2,4-二氨基喹唑啉及其相关化合物对哺乳动物二氢叶酸还原酶的抑制作用。

J Med Chem. 1974 Sep;17(9):943-7. doi: 10.1021/jm00255a007.

New perspectives on the chemotherapy of malaria, filariasis, and leprosy.

Prog Drug Res. 1974;18:99-172. doi: 10.1007/978-3-0348-7087-0_10.

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