Patterson R, Talbot C H, Roberts M
Clin Exp Immunol. 1972 Feb;10(2):267-74.
Two groups of Rhesus monkeys were previously established. One group included animals with immediate-type responses to respiratory challenge with ascaris antigen. The second group included animals with no respiratory reactivity to aerosol challenge with the same antigen. Both groups of Rhesus monkeys were subjected to controlled respiratory challenge with rabbit anti-human IgE. This anti-human IgE had sufficient cross reactivity with rhesus IgE to produce both the expected reverse passive cutaneous reactions and an acute respiratory response to aerosol challenge in five of six monkeys. The respiratory response to anti-IgE has been termed the reverse passive respiratory reaction. The characteristics of respiratory responses in animals reacting to anti-IgE were compared with those resulting from ascaris antigen challenge. The reverse passive respiratory reactions meet the criteria which have been established for the other acute previously described IgE mediated respiratory responses in Rhesus monkeys.
先前建立了两组恒河猴。一组包括对蛔虫抗原进行呼吸道激发产生速发型反应的动物。第二组包括对相同抗原气溶胶激发无呼吸道反应性的动物。两组恒河猴均接受兔抗人IgE的控制性呼吸道激发。这种抗人IgE与恒河猴IgE具有足够的交叉反应性，在六只猴子中有五只产生了预期的反向被动皮肤反应和气溶胶激发后的急性呼吸道反应。对抗IgE的呼吸道反应被称为反向被动呼吸道反应。将对抗IgE产生反应的动物的呼吸道反应特征与蛔虫抗原激发所产生的反应特征进行了比较。反向被动呼吸道反应符合先前为恒河猴中其他急性IgE介导的呼吸道反应所确立的标准。
