49例晚期乳腺癌患者双侧卵巢切除术的临床反应、雌激素受体与尿雄激素排泄之间的相关性

Correlation between clinical response to bilateral oophorectomy, estrogen receptors and urinary androgen excretion in 49 patients with advanced breast cancer.

作者信息

Preda F, Pizzocaro G, Oriana S, Riboldi G, Severini A, Di Fronzo G, Secreto G, Grattarola R

出版信息

Tumori. 1979 Jun 30;65(3):325-30. doi: 10.1177/030089167906500307.

Abstract

The aim of this study was to find out if it is possible to predict the clinical response to bilateral oophorectomy in premenopausal patients with advanced breast cancer. Two methods of determination were used before oophorectomy: 1) the presence of estrogen receptors in the tumor tissue; 2) the urinary concentration of androgens. The clinical response to oophorectomy was evaluated after a six-month follow-up. Determinations carried out on 49 patients showed that a significant correlation exists between clinical response to oophorectomy and androgenic activity alone or in combination with estrogen receptors when both tests give concordant results.

摘要

本研究的目的是确定对于绝经前晚期乳腺癌患者，是否有可能预测双侧卵巢切除术的临床反应。在卵巢切除术前采用了两种测定方法：1）肿瘤组织中雌激素受体的存在情况；2）尿液中雄激素的浓度。在六个月的随访后评估了卵巢切除术的临床反应。对49名患者进行的测定表明，当两项检测结果一致时，卵巢切除术的临床反应与单独的雄激素活性或与雌激素受体联合存在显著相关性。