Dao T L, Nemoto T
Cancer. 1980 Dec 15;46(12 Suppl):2779-82. doi: 10.1002/1097-0142(19801215)46:12+<2779::aid-cncr2820461407>3.0.co;2-r.
Estrogen receptors in breast tumors were assayed in 55 premenopausal women undergoing bilateral oophorectomy and in 120 postmenopausal women undergoing bilateral adrenalectomy for treatment of metastatic breast cancer. The data show that 20 (60%) of the 32 patients with estrogen receptor-positive (ER+) tumors had objective remission after oophorectomy, and 44 (51%) of the 87 patients with ER+ tumors responded to adrenalectomy. In contrast, of those patients with estrogen receptor-negative (ER-) tumors, only 3% had an objective remission following oophorectomy and 9% following adrenalectomy. It is concluded that major endocrine ablative procedures are not justified in patients with ER- tumors. The data also conclusively demonstrate the significance of 4S receptors in predicting the response to endocrine therapy. In this study, it was found that although the response rate to endocrine ablation was substantially higher (71-83%) in patients whose tumors contained both estradiol and progesterone receptors, between 50 and 60% of ER+ tumors lacking progesterone receptors had objective remission after endocrine ablative therapy.
对55名接受双侧卵巢切除术的绝经前女性和120名接受双侧肾上腺切除术以治疗转移性乳腺癌的绝经后女性的乳腺肿瘤中的雌激素受体进行了检测。数据显示，32例雌激素受体阳性（ER+）肿瘤患者中有20例（60%）在卵巢切除术后出现客观缓解，87例ER+肿瘤患者中有44例（51%）对肾上腺切除术有反应。相比之下，那些雌激素受体阴性（ER-）肿瘤患者中，只有3%在卵巢切除术后出现客观缓解，9%在肾上腺切除术后出现客观缓解。得出的结论是，对于ER-肿瘤患者，主要的内分泌切除手术是不合理的。数据还确凿地证明了4S受体在预测内分泌治疗反应中的重要性。在本研究中，发现尽管肿瘤同时含有雌二醇和孕酮受体的患者对内分泌切除的反应率显著更高（71-83%），但50%至60%缺乏孕酮受体的ER+肿瘤患者在内分泌切除治疗后出现了客观缓解。
