Modulation of cell behavior in vitro by the substratum in fibroblastic and leukemic mouse cell lines.

Fibroblastic and leukemic mouse cell lines were cultivated on a bovine serum albumin polymer covered with basic or acidic substances. Contact inhibition of fibroblast movement (cell overlapping) and division varied depending on prior treatment of the albumin polymer. The leukemic cells, which normally grow in suspension, attached and spread out on the polymers and could be carried as a monolayer. Preparation of surfaces capable of modulating different parameters of cell behavior in vitro is thus possible.