Bostock D E
Vet Pathol. 1979 Jan;16(1):32-40. doi: 10.1177/030098587901600103.
One hundred and thirty-four dogs from which melanomas had been excised were studied until death or for at least 2 years after surgery. Seven of 49 (14%) intraoral and lip tumours and 52 of 85 (61%) skin tumours were histologically benign; in spite of this, three of seven (43%) "benign" oral and four of 52 (8%) "benign" skin lesions led to the eventual death of the host. Thirty eight of 42 (90%) dogs with a histologically malignant melanoma of the lip or oral cavity died because of the tumour but only 15 of 33 (45%) with malignant skin melanomas died. Six of 59 (10%) dogs with a tumour of mitotic index 2 or less died from the tumour 2 years after surgery compared to 19 of 26 (73%) dogs having a tumour with a mitotic index of 3 or more.
对134只已切除黑色素瘤的犬进行了研究，直至其死亡或术后至少观察2年。49只口腔和唇部肿瘤中有7只（14%）、85只皮肤肿瘤中有52只（61%）组织学上为良性；尽管如此，7只“良性”口腔病变中有3只（43%）、52只“良性”皮肤病变中有4只（8%）最终导致宿主死亡。42只唇部或口腔组织学恶性黑色素瘤犬中有38只（90%）因肿瘤死亡，但33只恶性皮肤黑色素瘤犬中只有15只（约45%）死亡。有丝分裂指数为2或更低的肿瘤的59只犬中有6只（10%）在术后2年死于肿瘤，相比之下，有丝分裂指数为3或更高的肿瘤的26只犬中有19只（73%）死亡。
