Esplin D G
Animal Reference Pathology Division, ARUP Laboratories, Salt Lake City, UT 84108, USA.
Vet Pathol. 2008 Nov;45(6):889-96. doi: 10.1354/vp.45-6-889.
Postsurgical follow-up information was obtained on 64 dogs with 69 histologically well-differentiated melanocytic neoplasms that involved the mucous membranes of the lips and oral cavity. The patients received no adjunct therapy. Sixty one of 64 dogs (95%) were alive at the end of the study or had died of causes unrelated to the tumor, with a mean survival of 23.4 months and a median survival of 34 months after surgery. Twenty-eight dogs alive at the end of the study had a mean survival of 31.3 months after surgery. There were 2 dogs, which had recurrent tumors, that were still alive at the end of the study. All dogs that died of tumor-related causes (3) and all dogs with recurrent tumors (2) had tumors in the oral cavity. Results of this study indicate that a favorable clinical course and prolonged survival can be expected in most dogs with histologically well-differentiated melanocytic neoplasms of the mucous membranes of the lips and oral cavity, with only local excision of the lesions and no adjunct therapy.
我们获取了64只患有69个组织学上高分化黑素细胞性肿瘤的犬的术后随访信息，这些肿瘤累及唇部和口腔黏膜。这些患者未接受辅助治疗。64只犬中有61只（95%）在研究结束时存活或死于与肿瘤无关的原因，术后平均生存期为23.4个月，中位生存期为34个月。在研究结束时存活的28只犬术后平均生存期为31.3个月。有2只患有复发性肿瘤的犬在研究结束时仍然存活。所有死于肿瘤相关原因的犬（3只）和所有患有复发性肿瘤的犬（2只）口腔均有肿瘤。本研究结果表明，对于大多数唇部和口腔黏膜组织学上高分化黑素细胞性肿瘤的犬，仅对病变进行局部切除且不进行辅助治疗，可预期有良好的临床病程和延长的生存期。
