Jori G P, Buonanno G
Gut. 1972 Aug;13(8):610-3. doi: 10.1136/gut.13.8.610.
Hepatic biopsy showed either persistent or aggressive chronic hepatitis in 11 patients with cryoglobulinaemia not attributable to known disease entities, whereas liver impairment was not in every case suggested by either physical examination or functional abnormalities. The incidence was predominantly in women and cryoglobulin behaviour was similar in these patients and in five subjects with cirrhosis-associated cryoglobulinaemia. It is concluded that liver disease should be included among the constant features of the cryoglobulin-associated syndrome, and the speculation is advanced that in cryoglobulinaemic patients both cirrhosis and chronic hepatitis may be caused by the same pathogenic mechanism(s).
肝活检显示，11例病因不明的冷球蛋白血症患者存在持续性或侵袭性慢性肝炎，然而，体格检查或功能异常并非在每例患者中都提示有肝脏损害。发病率主要见于女性，这些患者以及5例与肝硬化相关的冷球蛋白血症患者的冷球蛋白表现相似。结论是，肝脏疾病应被纳入冷球蛋白相关综合征的常见特征之中，并且有人提出一种推测，即冷球蛋白血症患者的肝硬化和慢性肝炎可能由相同的致病机制引起。
