Druet P, Letonturier P, Contet A, Mandet C
Clin Exp Immunol. 1973 Dec;15(4):483-96.
The frequency of cryoglobulinaemia was statistically significant in acute proliferative endocapillary glomerulonephritis, in membrano-proliferative glomerulonephritis and in lupus glomerulonephritis. They all have in common glomerular cellular proliferation and glomerular deposits of C3. The cryoglobulins in most of these cases contain IgG and IgM. Except for acute proliferative endocapillary glomerulonephritis, a rather good correlation was observed between the cryoglobulin constituents and the immunoglobulins present in the glomerular tuft. Rheumatoid factor was very rarely found in the serum of these patients. A cryoglobulin characterized by the presence of the three immunoglobulins was also found in cirrhosis of the liver with or without proven glomerulonephritis.
冷球蛋白血症的发生率在急性增殖性毛细血管内增生性肾小球肾炎、膜增生性肾小球肾炎和狼疮性肾小球肾炎中具有统计学意义。它们都有肾小球细胞增殖和C3的肾小球沉积这一共同特征。大多数这些病例中的冷球蛋白含有IgG和IgM。除急性增殖性毛细血管内增生性肾小球肾炎外，在冷球蛋白成分与肾小球内存在的免疫球蛋白之间观察到相当好的相关性。这些患者的血清中很少发现类风湿因子。在有或无确诊肾小球肾炎的肝硬化患者中也发现了一种以三种免疫球蛋白存在为特征的冷球蛋白。
