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Metabolic disposition of primidone and its metabolites in epileptic subjects after single and repeated administration.

作者信息

Gallagher B B, Baumel I P, Mattson R H

出版信息

Neurology. 1972 Nov;22(11):1186-92. doi: 10.1212/wnl.22.11.1186.

DOI:10.1212/wnl.22.11.1186
PMID:4628597
Abstract
摘要

相似文献

1
Metabolic disposition of primidone and its metabolites in epileptic subjects after single and repeated administration.
Neurology. 1972 Nov;22(11):1186-92. doi: 10.1212/wnl.22.11.1186.
2
Phenylethylmalonamide (PEMA). An important metabolite of primidone.
Arch Neurol. 1972 Jul;27(1):34-41. doi: 10.1001/archneur.1972.00490130036005.
3
The metabolic conversion of primidone (Mysoline) to phenobarbitone in patients under long-term treatment. An attempt to estimate the independent effect of primidone.
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4
Bioavailability of primidone in epileptic patients.癫痫患者中扑米酮的生物利用度。
Int J Clin Pharmacol. 1974 Mar;9(2):132-7.
5
[On the combination treatment of epileptic attacks].[论癫痫发作的联合治疗]
Wien Med Wochenschr. 1968 Feb 10;118(6):116-8.
6
Variation in response to anticonvulsants in a group of epileptic patients.一组癫痫患者对抗惊厥药反应的差异。
Arch Neurol. 1972 Jul;27(1):29-33. doi: 10.1001/archneur.1972.00490130031004.
7
[Treatment of epilepsy in children].[儿童癫痫的治疗]
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8
[Problems of therapeutic service in primidone therapy].[扑米酮治疗中的治疗服务问题]
Z Arztl Fortbild (Jena). 1980 Aug 1;74(15):692-4.
9
Distribution of plasma phenobarbital, diphenylhydantoin and primidone levels in epileptic patients.
Folia Psychiatr Neurol Jpn. 1977;31(2):205-17. doi: 10.1111/j.1440-1819.1977.tb02721.x.
10
Drug treatment of epilepsy in childhood.儿童癫痫的药物治疗
Br Med J. 1969 Nov 22;4(5681):475-7. doi: 10.1136/bmj.4.5681.475.

引用本文的文献

1
Placental transfer and pharmacokinetics of primidone and its metabolites phenobarbital, PEMA and hydroxyphenobarbital in neonates and infants of epileptic mothers.
Eur J Clin Pharmacol. 1980 Jul;18(1):31-42. doi: 10.1007/BF00561476.
2
Phenytoin: an inhibitor and inducer of primidone metabolism in an epileptic patient.苯妥英：一名癫痫患者中扑米酮代谢的抑制剂和诱导剂。
Br J Clin Pharmacol. 1982 Aug;14(2):294-7. doi: 10.1111/j.1365-2125.1982.tb01980.x.
3
Pharmacologically active metabolites of drugs and other foreign compounds. Clinical, pharmacological, therapeutic and toxicological considerations.药物及其他外来化合物的药理活性代谢产物。临床、药理、治疗及毒理学考量。
Drugs. 1982 Dec;24(6):519-42. doi: 10.2165/00003495-198224060-00003.
4
Single-dose kinetics of primidone in acute viral hepatitis.扑米酮在急性病毒性肝炎中的单剂量动力学
Eur J Clin Pharmacol. 1984;27(4):465-9. doi: 10.1007/BF00549596.
5
Pharmacokinetics of phenylethylmalonamide (PEMA) in elderly men.
Eur J Clin Pharmacol. 1987;33(4):431-4. doi: 10.1007/BF00637644.
6
Primidone crystalluria following overdose. A report of a case and an analysis of the literature.过量服用后出现扑米酮结晶尿。一例报告及文献分析。
Med Toxicol Adverse Drug Exp. 1987 Sep-Oct;2(5):383-7. doi: 10.1007/BF03259955.
7
Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure.药理活性药物代谢物：治疗及毒性活性、人体血浆及尿液数据、肾衰竭时的蓄积情况
Clin Pharmacokinet. 1976 Nov-Dec;1(6):426-43. doi: 10.2165/00003088-197601060-00003.
8
Primidone metabolism in renal insufficiency and acute intoxication.
J Neurol. 1979 Aug;221(2):101-4. doi: 10.1007/BF00313107.
9
The effect of phenytoin and ethosuximide on primidone metabolism in patients with epilepsy.
J Neurol. 1975 Jun 9;209(2):115-23. doi: 10.1007/BF00314604.