Emanuél' N M, Konovalova N P, Volkova L M, Rusanov V V
Vopr Onkol. 1979;25(6):96-100.
The effectiveness of the combined therapy of leukemia P-388 with cyclophosphane and diazane was studied. The pattern of administering these substances was selected with due consideration of the cyclospecificity of their action. In a number of cases considerable synergism was observed, resulting in a cure of 100% of animals. Estimation of the effectiveness and the degree of synergism was made by the method of fractionation analysis, which allowed delineating some trends for providing the optimum combined therapy.
研究了环磷酰胺和二氮嗪联合治疗白血病P - 388的效果。在给药时充分考虑了这些物质作用的环特异性来选择给药方式。在一些病例中观察到了显著的协同作用，使得100%的动物被治愈。通过分级分析方法对疗效和协同程度进行了评估，这有助于勾勒出一些实现最佳联合治疗的趋势。
