人体抗狂犬病疫苗接种后的抗体及免疫球蛋白反应。

Antibody and immunoglobulin response to antirabies vaccination in man.

作者信息

Cho H C, Fenje P, Sparkes J D

出版信息

Infect Immun. 1972 Oct;6(4):483-6. doi: 10.1128/iai.6.4.483-486.1972.

DOI:10.1128/iai.6.4.483-486.1972

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422562/

Abstract

Serum neutralization antibody and immunoglobulin responses in 30 individuals were studied in paired serum samples which had been obtained before and 2 to 3 weeks after the administration of a recall dose of rabies tissue culture vaccine. The immune reaction consisted of a predominantly immunoglobulin G (IgG) antibody response. Also, a significant increase in neutralizing antibody titers was observed, but without a consistently correlated change of the IgG levels in the individual serum samples. The radial immunodiffusion test appears to contain the elements necessary for the development of a routine test to determine rabies antibody in single serum samples.

摘要

对30名个体的血清中和抗体及免疫球蛋白反应进行了研究，采用配对血清样本，这些样本在给予一剂狂犬病组织培养疫苗回忆剂量之前以及之后2至3周采集。免疫反应主要由免疫球蛋白G（IgG）抗体反应组成。此外，观察到中和抗体滴度显著增加，但个体血清样本中的IgG水平没有一致的相关性变化。放射免疫扩散试验似乎包含了开发用于测定单份血清样本中狂犬病抗体的常规检测所需的要素。

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