体外给予格列本脲后培养的小鼠胰岛的胰岛素分泌及（前）胰岛素生物合成
Insulin secretion and (pro)insulin biosynthesis of cultured mice islets after glibenclamide loading in vitro.
作者信息
Ziegler B, Wilke B, Ziegler M, Schmidt S, Zühlke H
出版信息
Experientia. 1980 Apr 15;36(4):467-8. doi: 10.1007/BF01975151.
PMID:6769698
Abstract
Isolated islets from C57Bl/6J mice exposed to 10 mmoles/l glucose supplemented with 5 micrograms/ml glibenclamide for 48 h released significantly less insulin in the subsequent short-time incubation than untreated controls (without glibenclamide), whereas insulin biosynthesis was not suppressed by glibenclamide treatment.
摘要
将来自C57Bl/6J小鼠的分离胰岛暴露于补充有5微克/毫升格列本脲的10毫摩尔/升葡萄糖中48小时，在随后的短时间孵育中，其释放的胰岛素明显少于未处理的对照（无格列本脲），而格列本脲处理并未抑制胰岛素生物合成。
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