[Structure of the genomes of recombinant strains of influenza A viruses with various antigenic and biological properties].

Genomes of influenza A/WSN/33, A/Singapore/57 and recombinant X-7 and X-9 viruses were studied by the method of molecular hybridization followed by electrophoretic separation of RNA-duplexes in polyacrylamide gel. The genome of the recombinant X-7 influenza virus strain was found to contain fragments V and VII of RNA corresponding to fragments of A/Singapore/57 RNA, whereas fragments III, IV, and VIII were derived from influenza A/WSN/33 virus. Recombinant X-9 had fragments III, IV, and VII of RNA similar to those of A/Singapore/57, and fragments V,VIII of RNA derived from influenza A/WSN/33 virus. Resistance to rimantadine in influenza viruses correlated in X-7 and X-9 recombinants to the strain appurtenance of fragment VIII.