Bean W J, Cox N J, Kendal A P
Nature. 1980 Apr 17;284(5757):638-40. doi: 10.1038/284638a0.
In 1977, a unique event occurred in the epidemiology of influenza when a virus of the influenza A (H1N1) subtype, similar to a virus that had occurred in 1950, reappeared and caused worldwide epidemics but did not replace the prevailing influenza A (H2N2) subtype. Consequently, the two viruses co-circulated throughout the world and mixed infection of some individuals with both virus strains was detected, raising the possiblitity that recombination between the two strains might affect the future epidemiological behaviour of influenza. Serological analysis of virus isolates from influenza outbreaks during the winter of 1978-79, however, failed to detect any antigenic hybrids (H2N1 or H1N2). The investigation described here, was therefore, undertaken to detect recombinants among recent isolates of the H1N1 and H3N1 serotypes, involving genes coding for other than the surface proteins by RNA-RNA hybridisation. We report here the genetic characterisation of recombinants of both antigenic types.
1977年，流感流行病学领域发生了一件独特的事情，甲型（H1N1）亚型流感病毒再次出现，它与1950年出现的一种病毒相似，引发了全球范围的流行，但并未取代当时流行的甲型（H2N2）亚型病毒。结果，这两种病毒在全球共同传播，检测到一些个体同时感染了这两种病毒株，这增加了两种病毒株之间发生重组可能影响流感未来流行病学特征的可能性。然而，对1978 - 1979年冬季流感爆发期间分离出的病毒进行血清学分析，未能检测到任何抗原杂种（H2N1或H1N2）。因此，开展了此处所述的研究，通过RNA - RNA杂交检测H1N1和H3N1血清型近期分离株中的重组体，这些重组体涉及编码除表面蛋白之外其他蛋白的基因。我们在此报告两种抗原类型重组体的基因特征。
