黑腹果蝇核糖体RNA和5s RNA合成的调控。I. 截毛突变体
Regulation of ribosomal RNA and 5s RNA synthesis in Drosophila melanogaster. I. Bobbed mutants.
作者信息
Weinmann R
出版信息
Genetics. 1972 Oct;72(2):267-76. doi: 10.1093/genetics/72.2.267.
Abstract
Analysis of the rates and amounts of rRNA and 5s RNA synthesized in Drosophila melanogaster bobbed mutants was done by using acrylamide-gel electrophoresis. The results show that the amounts of rRNA synthesized are constant, although the rates of rRNA synthesis in bb's are reduced to 30% of the wild-type level. The rates of synthesis of 5s RNA were constant. The rate of synthesis of the two kinds of molecules that enter in equimolar amounts into the mature ribosome is non-coordinated.-The rates of rRNA synthesis were shown to be proportional to the length of the scutellar bristles, supporting the notion that in trichogen cells there is no developmental delay, but the size of the bristle depends directly on the rate of rRNA synthesis.
摘要
通过使用丙烯酰胺凝胶电泳对黑腹果蝇截毛突变体中合成的rRNA和5s RNA的速率及数量进行了分析。结果表明，尽管bb突变体中rRNA的合成速率降至野生型水平的30%，但合成的rRNA数量是恒定的。5s RNA的合成速率是恒定的。以等摩尔量进入成熟核糖体的两种分子的合成速率是不协调的。rRNA的合成速率与小盾刚毛的长度成正比，这支持了在毛原细胞中不存在发育延迟，而是刚毛大小直接取决于rRNA合成速率的观点。
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