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1
The synthesis of 5S RNA and its relationship to 18S and 28S ribosomal RNA in the bobbed mutants of Drosophila melanogaster.黑腹果蝇截毛突变体中5S RNA的合成及其与18S和28S核糖体RNA的关系。
Genetics. 1975 Dec;81(4):723-38. doi: 10.1093/genetics/81.4.723.
2
26S and 18S rRNA synthesis in bobbed mutants of Drosophila melanogaster.黑腹果蝇截毛突变体中26S和18S核糖体RNA的合成
Biochimie. 1981;63(5):451-5. doi: 10.1016/s0300-9084(81)80020-x.
3
Regulation of ribosomal RNA and 5s RNA synthesis in Drosophila melanogaster. I. Bobbed mutants.黑腹果蝇核糖体RNA和5s RNA合成的调控。I. 截毛突变体
Genetics. 1972 Oct;72(2):267-76. doi: 10.1093/genetics/72.2.267.
4
Genetic analysis of the 5S RNA genes in Drosophila melanogaster.黑腹果蝇5S RNA基因的遗传分析
Genetics. 1975 Nov;81(3):515-23. doi: 10.1093/genetics/81.3.515.
5
Control of 5S RNA synthesis during early development of anucleolate and partial nucleolate mutants of Xenopus laevis.非洲爪蟾无核仁及部分核仁突变体早期发育过程中5S RNA合成的调控
J Cell Biol. 1973 Dec;59(3):624-32. doi: 10.1083/jcb.59.3.624.
6
Ribosomal DNA and its expression in Drosophila melanogaster during growth and development.核糖体DNA及其在黑腹果蝇生长发育过程中的表达。
Mol Gen Genet. 1976 Aug 19;147(2):217-23. doi: 10.1007/BF00267574.
7
Regulation in rDNA-deficient Drosophila melanogaster.rDNA 缺陷型黑腹果蝇中的调控
Cell. 1975 Mar;4(3):275-80. doi: 10.1016/0092-8674(75)90176-2.
8
Levels of RNA and DNA in Drosophila melanogaster at different stages of development: a comparison between one bobbed and two phenotypically non-bobbed stocks.黑腹果蝇发育不同阶段的RNA和DNA水平：一个截毛品系与两个表型非截毛品系的比较
Biochem Genet. 1972 Apr;6(2):217-30. doi: 10.1007/BF00486405.
9
Base sequence complexity of the stable RNA species of Drosophila melanogaster.黑腹果蝇稳定RNA种类的碱基序列复杂性。
Biochemistry. 1976 Dec 14;15(25):5511-9. doi: 10.1021/bi00670a015.
10
Genetic modulation of RNA metabolism in Drosophila. III. Requirement for an rDNA-deficient X chromosome in YbbSuVar-3-mediated increases in RNA synthesis.果蝇中RNA代谢的遗传调控。III. YbbSuVar-3介导的RNA合成增加对X染色体rDNA缺陷的需求。
Genetics. 1979 Oct;93(2):411-22. doi: 10.1093/genetics/93.2.411.

引用本文的文献

1
Ribosomal DNA and its expression in Drosophila melanogaster during growth and development.核糖体DNA及其在黑腹果蝇生长发育过程中的表达。
Mol Gen Genet. 1976 Aug 19;147(2):217-23. doi: 10.1007/BF00267574.
2
Genetic modulation of RNA metabolism in Drosophila. II. Coordinate rate change in 4S, 5S, and poly-A associated RNA synthesis.果蝇中RNA代谢的遗传调控。II. 4S、5S和多聚腺苷酸相关RNA合成的协同速率变化。
Genetics. 1977 Aug;86(4):801-11. doi: 10.1093/genetics/86.4.801.
3
Genetic modulation of RNA metabolism in Drosophilia. I. Increased rate of ribosomal RNA synthesis.果蝇RNA代谢的遗传调控。I.核糖体RNA合成速率增加。
Genetics. 1977 Aug;86(4):789-800. doi: 10.1093/genetics/86.4.789.
4
Genetic modulation of RNA metabolism in Drosophila. III. Requirement for an rDNA-deficient X chromosome in YbbSuVar-3-mediated increases in RNA synthesis.果蝇中RNA代谢的遗传调控。III. YbbSuVar-3介导的RNA合成增加对X染色体rDNA缺陷的需求。
Genetics. 1979 Oct;93(2):411-22. doi: 10.1093/genetics/93.2.411.

本文引用的文献

1
Sedimentation characteristics of rapidly labelled RNA from HeLa cells.来自海拉细胞的快速标记RNA的沉降特性。
Biochem Biophys Res Commun. 1962 Jun 4;7:486-90. doi: 10.1016/0006-291x(62)90341-8.
2
Sequence heterogeneity of 5 S RNA in Xenopus laevis.非洲爪蟾5S RNA的序列异质性
FEBS Lett. 1972 Sep 1;25(1):13-20. doi: 10.1016/0014-5793(72)80443-5.
3
Sedimentation properties of the newly synthesized RNA from isolated nuclear components of Chironomus tentans salivary gland cells.摇蚊唾液腺细胞分离核成分中新合成RNA的沉降特性。
J Mol Biol. 1967 Sep 14;28(2):331-43. doi: 10.1016/s0022-2836(67)80013-5.
4
Persistent synthesis of 5S RNA when production of 28S and 18S ribosomal RNA is inhibited by low doses of actinomycin D.当低剂量放线菌素D抑制28S和18S核糖体RNA的产生时，5S RNA持续合成。
J Cell Physiol. 1968 Dec;72(3):235-46. doi: 10.1002/jcp.1040720311.
5
Studies of fractionated HeLa cell metaphase chromosomes. II. chromosomal distribution of sites for transfer RNA and 5 s RNA.对HeLa细胞中期染色体分段的研究。II. 转运RNA和5 s RNA位点的染色体分布。
J Mol Biol. 1971 Mar 28;56(3):555-63. doi: 10.1016/0022-2836(71)90401-3.
6
Molecular hybridization of Chinese hamster 5S, 4S and "pulse-labelled" RNA in cytological preparations.中国仓鼠5S、4S和“脉冲标记”RNA在细胞学制剂中的分子杂交。
Exp Cell Res. 1971 Apr;65(2):329-34. doi: 10.1016/0014-4827(71)90009-7.
7
The 5 s RNA genes of Drosophila melanogaster.黑腹果蝇的5S RNA基因。
J Mol Biol. 1970 Jul 28;51(2):171-83. doi: 10.1016/0022-2836(70)90135-x.
8
Localization of 5S RNA genes on Drosophila chromosomes by RNA-DNA hybridization.通过RNA-DNA杂交对果蝇染色体上5S RNA基因进行定位
Science. 1970 Nov 6;170(3958):639-41. doi: 10.1126/science.170.3958.639.
9
Regulation of ribosomal RNA synthesis and its bearing on the bobbed phenotype in Drosophila melanogaster.黑腹果蝇核糖体RNA合成的调控及其与截毛表型的关系。
Dev Biol. 1970 Jul;22(3):495-512. doi: 10.1016/0012-1606(70)90165-x.
10
Synthesis and properties of ribosomal RNA in Drosophila.果蝇核糖体RNA的合成与特性
J Mol Biol. 1969 Nov 28;46(1):85-98. doi: 10.1016/0022-2836(69)90059-x.

黑腹果蝇截毛突变体中5S RNA的合成及其与18S和28S核糖体RNA的关系。

The synthesis of 5S RNA and its relationship to 18S and 28S ribosomal RNA in the bobbed mutants of Drosophila melanogaster.

作者信息

Mohan J

出版信息

Genetics. 1975 Dec;81(4):723-38. doi: 10.1093/genetics/81.4.723.

DOI:10.1093/genetics/81.4.723
PMID:814039
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213430/
Abstract

Ribosomes contain one molecule each of 5S, 18S and 28S RNA. In Drosophila melanogaster although the genes for 18S + 28S are physically separated from the 5S RNA genes, the multiplicity of various ribosomal RNA genes is roughly the same. Thus a coordinate synthesis of these three molecules might seem feasible. This problem has been approached by determining the molar ratios of various RNA's in ovaries and in adult flies. In ovaries there is a slight excess of 5S RNA molecules over other rRNA's, but in adult flies no such differences exist. Bobbed mutants also have the same molar ratios as wild-type flies. Results on 5S RNA synthesis in both in vitro and in vivo studies show that it is reduced in coordination with 18S + 28S rRNA in the bobbed mutants of Drosophila melanogaster. Various possibilities are discussed in considering the implications of these results.

摘要

核糖体包含一个5S、一个18S和一个28S RNA分子。在黑腹果蝇中，虽然18S + 28S的基因在物理上与5S RNA基因分离，但各种核糖体RNA基因的数量大致相同。因此，这三种分子的协同合成似乎是可行的。这个问题已经通过测定卵巢和成年果蝇中各种RNA的摩尔比来解决。在卵巢中，5S RNA分子比其他rRNA略有过量，但在成年果蝇中不存在这种差异。截毛突变体也与野生型果蝇具有相同的摩尔比。体外和体内研究中关于5S RNA合成的结果表明，在黑腹果蝇的截毛突变体中，它与18S + 28S rRNA的合成协同减少。在考虑这些结果的影响时，讨论了各种可能性。