Abioye A A, Lewis E A, McFarlane H
Immunology. 1972 Dec;23(6):937-46.
In eighty-nine adult Nigerians, with clinical and asymptomatic amoebiasis and in patients with conditions other than amoebiasis, serum concentrations of immunoglobulins (G, A and M) are presented as geometric mean values (mg/ml). Statistical analysis revealed a significant relationship between active symptomatic amoebiasis and raised IgG concentrations in all the groups studied except in pregnant and post-partum states. In contrast, analyses of the IgA and IgM data showed no significant correlation except in males with amoebic dysentery; and in males with amoebic liver abscess in which the respective immunoglobulins are significantly raised (Table 1). Estimation of immunoglobulin levels during a follow-up study in fifteen amoebiasis patients showed a tendency for IgG to fall appreciably with treatment of the disease. The role of humoral immune responses in amoebiasis is discussed in the light of the low levels found in pregnancy and post-partum states, when the disease is known to be most severe.
在89名患有临床和无症状阿米巴病的成年尼日利亚人以及患有除阿米巴病以外其他疾病的患者中，免疫球蛋白（G、A和M）的血清浓度以几何平均值（mg/ml）呈现。统计分析表明，除妊娠和产后状态外，在所有研究组中，活动性症状性阿米巴病与升高的IgG浓度之间存在显著关系。相比之下，对IgA和IgM数据的分析显示，除了患有阿米巴痢疾的男性以及患有阿米巴肝脓肿且各自免疫球蛋白显著升高的男性外，没有显著相关性（表1）。在对15名阿米巴病患者的随访研究中，免疫球蛋白水平的估计显示，随着疾病的治疗，IgG有明显下降的趋势。鉴于在妊娠和产后状态下发现的低水平，而此时已知该病最为严重，因此讨论了体液免疫反应在阿米巴病中的作用。
