Charlesworth B, Charlesworth D
Genetics. 1973 Feb;73(2):351-9. doi: 10.1093/genetics/73.2.351.
This paper presents the results of a study of linkage disequilibrium between five polymorphic enzyme genes located on chromosome 3 of D. melanogaster. Three sets of chromosomes were examined: two represented samples from successive years of the same natural population, and one came from a large laboratory population. Out of the thirty possible tests for linkage disequilibrium between pairs of loci, two were significant at the 5% level and two at the 1% level. This result cannot reasonably be ascribed to chance alone. The pairs of loci that had a significant correlation in one sample had higher than average correlations in the other samples (though not necessarily in the same direction); this effect was highly significant statistically. There was no tendency for the high correlations to be associated with tightness of linkage between the loci concerned. All five loci were involved in at least one significant effect. It was concluded that these results are difficult to explain on the neutral allele theory of protein polymorphism, but are consistent with the concept of selective control of allele frequencies.
本文展示了一项关于果蝇3号染色体上五个多态性酶基因之间连锁不平衡的研究结果。研究检查了三组染色体：两组代表来自同一自然种群连续年份的样本，另一组来自一个大型实验室种群。在对位点对之间连锁不平衡的三十种可能测试中，有两种在5%水平上显著，两种在1%水平上显著。这个结果不能合理地仅归因于偶然。在一个样本中具有显著相关性的位点对在其他样本中具有高于平均水平的相关性（尽管不一定是相同方向）；这种效应在统计上非常显著。高相关性与相关位点之间的连锁紧密程度没有关联趋势。所有五个位点都至少涉及一个显著效应。得出的结论是，这些结果难以用蛋白质多态性的中性等位基因理论来解释，但与等位基因频率的选择性控制概念一致。
