Animal model of human disease. Crigler-Najjar Syndrome. Animal model: hereditary nonhemolytic unconjugated hyperbilirubinemia in Gunn rats.
作者信息
Cornelius C E, Arias I M
出版信息
Am J Pathol. 1972 Nov;69(2):369-72.
Abstract
摘要
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Prolonged neonatal jaundice: a manifestation of heterozygote state for Crigler--Najjar syndrome?
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Gunn rat: a model for inherited deficiency of bilirubin glucuronidation.冈田鼠：一种遗传性胆红素葡萄糖醛酸化缺陷模型。
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Regulation of microsomal enzymes by phospholipids. VI. Abnormal enzyme-lipid interactions in liver microsomes from Gunn rats.磷脂对微粒体酶的调节。VI. 冈恩大鼠肝脏微粒体中异常的酶 - 脂质相互作用
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A translationally optimized AAV-UGT1A1 vector drives safe and long-lasting correction of Crigler-Najjar syndrome.一种经翻译优化的腺相关病毒-尿苷二磷酸葡萄糖醛酸基转移酶1A1（AAV-UGT1A1）载体可实现克里格勒-纳贾尔综合征的安全且持久的矫正。
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The use of jejunal transplants to treat a genetic enzyme deficiency.使用空肠移植治疗一种遗传性酶缺乏症。
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Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver.人肝脏中尿苷二磷酸葡萄糖醛酸基转移酶对胆红素和2-氨基苯酚活性的产后发育
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Stimulation of defective Gunn-rat liver uridine diphosphate glucuronyltransferase activity in vitro by alkyl ketones.烷基酮对体外培养的缺陷型冈恩大鼠肝脏尿苷二磷酸葡萄糖醛酸基转移酶活性的刺激作用。
Biochem J. 1979 Mar 1;177(3):993-5. doi: 10.1042/bj1770993.
本文引用的文献
1
HEREDITARY JAUNDICE IN THE RAT.大鼠中的遗传性黄疸
Can Med Assoc J. 1940 Feb;42(2):122-5.
2
Kernicterus in rats with an inherited deficiency of glucuronyl transferase.患有遗传性葡糖醛酸转移酶缺乏症大鼠的核黄疸
AMA J Dis Child. 1959 May;97(5, Part 1):591-608. doi: 10.1001/archpedi.1959.02070010593009.
3
Congenital familial nonhemolytic jaundice with kernicterus.伴有核黄疸的先天性家族性非溶血性黄疸
Pediatrics. 1952 Aug;10(2):169-80.
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