烷基酮对体外培养的缺陷型冈恩大鼠肝脏尿苷二磷酸葡萄糖醛酸基转移酶活性的刺激作用。
Stimulation of defective Gunn-rat liver uridine diphosphate glucuronyltransferase activity in vitro by alkyl ketones.
作者信息
Lalani E N, Burchell B
出版信息
Biochem J. 1979 Mar 1;177(3):993-5. doi: 10.1042/bj1770993.
Abstract
Addition of alkyl ketone (10mM) to Gunn-rat liver homogenates increased UDP-glucuronyltransferase activity towards 2-aminophenol by 10--20 fold, up to enhanced values of enzyme activity observed with similarly treated Wistar-rat liver homogenates. Alkyl ketones also activate the defective enzyme purified from Gunn-rat liver. This genetic deficiency of UDP-glucuronyltransferase activity is no longer apparent when assayed in the presence of alkyl ketones.
摘要
向冈恩大鼠肝脏匀浆中添加烷基酮（10mM）可使针对2-氨基酚的UDP-葡萄糖醛酸基转移酶活性增加10至20倍，达到用类似处理的Wistar大鼠肝脏匀浆所观察到的酶活性增强值。烷基酮还能激活从冈恩大鼠肝脏中纯化出的缺陷酶。当在烷基酮存在的情况下进行测定时，UDP-葡萄糖醛酸基转移酶活性的这种遗传缺陷不再明显。
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本文引用的文献
1
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J Biol Chem. 1951 Nov;193(1):265-75.
2
Hepatic UDP-glucuronyltransferase in Wistar and Gunn rats--in vitro activation by diethylnitrosamine.Wistar大鼠和Gunn大鼠肝脏中的UDP-葡萄糖醛酸转移酶——二乙基亚硝胺的体外激活作用
Biochem Biophys Res Commun. 1968 Sep 6;32(5):866-72. doi: 10.1016/0006-291x(68)90321-5.
3
Studies on the activation in vitro of glucuronyltransferase.葡萄糖醛酸转移酶体外激活的研究。
Biochim Biophys Acta. 1969 Nov 4;191(2):279-91. doi: 10.1016/0005-2744(69)90247-2.
4
Regulation of microsomal enzymes by phospholipids. VI. Abnormal enzyme-lipid interactions in liver microsomes from Gunn rats.磷脂对微粒体酶的调节。VI. 冈恩大鼠肝脏微粒体中异常的酶 - 脂质相互作用
Biochim Biophys Acta. 1973 Feb 28;297(2):497-502. doi: 10.1016/0304-4165(73)90097-4.
5
Assay and properties of dititonin-activated bilirubin uridine diphosphate glucuronyltransferase from rat liver.大鼠肝脏中地衣皂苷激活的胆红素尿苷二磷酸葡萄糖醛酸基转移酶的测定及性质
Biochem J. 1972 Sep;129(3):605-18. doi: 10.1042/bj1290605.
6
7
Inhibition of hexobarbital metabolism by diethylnitrosamine.
Biochem Pharmacol. 1968 May;17(5):842-5. doi: 10.1016/0006-2952(68)90027-0.
8
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.一种利用蛋白质 - 染料结合原理对微克级蛋白质进行定量的快速灵敏方法。
Anal Biochem. 1976 May 7;72:248-54. doi: 10.1016/0003-2697(76)90527-3.
9
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FEBS Lett. 1978 Mar 15;87(2):207-11. doi: 10.1016/0014-5793(78)80333-0.
10
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