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烷基酮对体外培养的缺陷型冈恩大鼠肝脏尿苷二磷酸葡萄糖醛酸基转移酶活性的刺激作用。

Stimulation of defective Gunn-rat liver uridine diphosphate glucuronyltransferase activity in vitro by alkyl ketones.

作者信息

Lalani E N, Burchell B

出版信息

Biochem J. 1979 Mar 1;177(3):993-5. doi: 10.1042/bj1770993.

DOI:10.1042/bj1770993
PMID:109085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1186469/
Abstract

Addition of alkyl ketone (10mM) to Gunn-rat liver homogenates increased UDP-glucuronyltransferase activity towards 2-aminophenol by 10--20 fold, up to enhanced values of enzyme activity observed with similarly treated Wistar-rat liver homogenates. Alkyl ketones also activate the defective enzyme purified from Gunn-rat liver. This genetic deficiency of UDP-glucuronyltransferase activity is no longer apparent when assayed in the presence of alkyl ketones.

摘要

向冈恩大鼠肝脏匀浆中添加烷基酮（10mM）可使针对2-氨基酚的UDP-葡萄糖醛酸基转移酶活性增加10至20倍，达到用类似处理的Wistar大鼠肝脏匀浆所观察到的酶活性增强值。烷基酮还能激活从冈恩大鼠肝脏中纯化出的缺陷酶。当在烷基酮存在的情况下进行测定时，UDP-葡萄糖醛酸基转移酶活性的这种遗传缺陷不再明显。

相似文献

1
Stimulation of defective Gunn-rat liver uridine diphosphate glucuronyltransferase activity in vitro by alkyl ketones.烷基酮对体外培养的缺陷型冈恩大鼠肝脏尿苷二磷酸葡萄糖醛酸基转移酶活性的刺激作用。
Biochem J. 1979 Mar 1;177(3):993-5. doi: 10.1042/bj1770993.
2
Immunochemical comparison of UDP-glucuronyltransferase from Gunn- and Wistar-rat livers.冈恩大鼠和Wistar大鼠肝脏中UDP-葡萄糖醛酸基转移酶的免疫化学比较。
Biochem J. 1980 Oct 1;191(1):155-63. doi: 10.1042/bj1910155.
3
Hepatic conversion of bilirubin monoglucuronide to diglucuronide in uridine diphosphate-glucuronyl transferase-deficient man and rat by bilirubin glucuronoside glucuronosyltransferase.胆红素葡糖苷酸葡糖醛酸基转移酶在尿苷二磷酸葡糖醛酸基转移酶缺陷的人和大鼠中，将单葡糖醛酸胆红素肝内转化为双葡糖醛酸胆红素。
J Clin Invest. 1978 Jul;62(1):191-6. doi: 10.1172/JCI109105.
4
Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver.人肝脏中尿苷二磷酸葡萄糖醛酸基转移酶对胆红素和2-氨基苯酚活性的产后发育
Biochem J. 1979 Dec 15;184(3):705-7. doi: 10.1042/bj1840705.
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The presence of a microsomal UDP-glucuronyl transferase for bilirubin in homozygous jaundiced Gunn rats and in the Crigler-Najjar syndrome.纯合子黄疸型冈恩大鼠及克里格勒-纳贾尔综合征中胆红素微粒体UDP-葡糖醛酸基转移酶的存在情况。
Hepatology. 1981 Jul-Aug;1(4):307-15. doi: 10.1002/hep.1840010405.
6
Abolition of the apparent deficiency of 2-aminophenol glucuronidation in perfused Gunn rat liver by pentan-3-one.
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Involvement of UDP-glucuronosyltransferase activity in irinotecan-induced delayed-onset diarrhea in rats.尿苷二磷酸葡萄糖醛酸基转移酶活性与伊立替康诱导的大鼠迟发性腹泻的关系。
Cancer Chemother Pharmacol. 2008 Apr;61(4):595-605. doi: 10.1007/s00280-007-0512-x. Epub 2007 Jun 5.

引用本文的文献

1
Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats.自发性糖尿病大鼠、丙酮处理大鼠和饥饿大鼠中胆红素UDP-葡萄糖醛酸基转移酶诱导的分子基础。
Biochem J. 1998 Dec 15;336 ( Pt 3)(Pt 3):587-92. doi: 10.1042/bj3360587.
2
Classification and genetic expression of Wistar rats with high and low hepatic microsomal UDP-glucuronosyltransferase activity towards androsterone.对雄甾酮具有高和低肝微粒体UDP-葡萄糖醛酸基转移酶活性的Wistar大鼠的分类及基因表达
Biochem J. 1982 Jan 15;202(1):171-4. doi: 10.1042/bj2020171.
3
Immunochemical comparison of UDP-glucuronyltransferase from Gunn- and Wistar-rat livers.冈恩大鼠和Wistar大鼠肝脏中UDP-葡萄糖醛酸基转移酶的免疫化学比较。
Biochem J. 1980 Oct 1;191(1):155-63. doi: 10.1042/bj1910155.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Hepatic UDP-glucuronyltransferase in Wistar and Gunn rats--in vitro activation by diethylnitrosamine.Wistar大鼠和Gunn大鼠肝脏中的UDP-葡萄糖醛酸转移酶——二乙基亚硝胺的体外激活作用
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Studies on the activation in vitro of glucuronyltransferase.葡萄糖醛酸转移酶体外激活的研究。
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Assay and properties of dititonin-activated bilirubin uridine diphosphate glucuronyltransferase from rat liver.大鼠肝脏中地衣皂苷激活的胆红素尿苷二磷酸葡萄糖醛酸基转移酶的测定及性质
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Animal model of human disease. Crigler-Najjar Syndrome. Animal model: hereditary nonhemolytic unconjugated hyperbilirubinemia in Gunn rats.人类疾病的动物模型。克里格勒-纳贾尔综合征。动物模型：冈恩大鼠遗传性非溶血性非结合胆红素血症。
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Inhibition of hexobarbital metabolism by diethylnitrosamine.
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.一种利用蛋白质 - 染料结合原理对微克级蛋白质进行定量的快速灵敏方法。
Anal Biochem. 1976 May 7;72:248-54. doi: 10.1016/0003-2697(76)90527-3.
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Reactivation of a pure defective UDP-glucuronyltransferase from homozygous Gunn rat liver.纯合子Gunn大鼠肝脏中纯合缺陷型UDP-葡萄糖醛酸基转移酶的重新激活。
FEBS Lett. 1978 Mar 15;87(2):207-11. doi: 10.1016/0014-5793(78)80333-0.
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Substrate specificity and properties of uridine diphosphate glucuronyltransferase purified to apparent homogeneity from phenobarbital-treated rat liver.从苯巴比妥处理的大鼠肝脏中纯化至表观均一的尿苷二磷酸葡萄糖醛酸基转移酶的底物特异性和性质。
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