人肝脏中尿苷二磷酸葡萄糖醛酸基转移酶对胆红素和2-氨基苯酚活性的产后发育
Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver.
作者信息
Onishi S, Kawade N, Itoh S, Isobe K, Sugiyama S
出版信息
Biochem J. 1979 Dec 15;184(3):705-7. doi: 10.1042/bj1840705.
Abstract
UDP-glucuronyltransferase activities towards 2-aminophenol and bilirubin were studied in a total of 70 human subjects, including premature and full-term newborn babies, infants, children and adults. These two activities have been reported in rat to develop latefoetally and neonatally respectively, but in man they both develop neonatally. There is a linear relationship between the logarithm of each liver transferase activity and the logarithm of the number of days after birth during the first 3 months of life, after which each activity remains constant.
摘要
在总共70名人类受试者中研究了尿苷二磷酸葡萄糖醛酸基转移酶对2-氨基酚和胆红素的活性，这些受试者包括早产儿和足月儿、婴儿、儿童及成年人。据报道，大鼠体内这两种活性分别在胎儿后期和新生儿期发育，但在人类中它们均在新生儿期发育。在生命的前3个月中，每种肝脏转移酶活性的对数与出生后天数的对数之间呈线性关系，此后每种活性保持恒定。
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本文引用的文献
1
SOME PROBLEMS IN EXPRESSING AND COMPARING BODY COMPOSITION DETERMINED BY DIRECT ANALYSIS.
Ann N Y Acad Sci. 1963 Sep 26;110:153-60. doi: 10.1111/j.1749-6632.1963.tb17081.x.
2
Determination of bilirubin UDP-glucuronyl transferase activity in needle-biopsy specimens of human liver.人肝穿刺活检标本中胆红素UDP-葡萄糖醛酸基转移酶活性的测定
Clin Chim Acta. 1970 Jul;29(1):27-35. doi: 10.1016/0009-8981(70)90216-0.
3
Studies on the activation in vitro of glucuronyltransferase.葡萄糖醛酸转移酶体外激活的研究。
Biochim Biophys Acta. 1969 Nov 4;191(2):279-91. doi: 10.1016/0005-2744(69)90247-2.
4
Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency. Clinical, biochemical, pharmacologic and genetic evidence for heterogeneity.伴有葡萄糖醛酸转移酶缺乏的慢性非溶血性非结合胆红素血症。异质性的临床、生化、药理学及遗传学证据。
Am J Med. 1969 Sep;47(3):395-409. doi: 10.1016/0002-9343(69)90224-1.
5
6
Recent advances in the separation and analysis of diazo-positive bile pigments.重氮阳性胆汁色素分离与分析的最新进展
Methods Biochem Anal. 1974;22:205-50. doi: 10.1002/9780470110423.ch5.
7
Critique of the assay and significance of bilirubin conjugation.胆红素结合试验的评析及其意义
Adv Clin Chem. 1973;16:239-88. doi: 10.1016/s0065-2423(08)60347-9.
8
Effects of phenobarbital and 3-methylcholanthrene on substrate specificity of rat liver microsomal UDP-glucuronyltransferase.苯巴比妥和3-甲基胆蒽对大鼠肝微粒体UDP-葡萄糖醛酸基转移酶底物特异性的影响。
Biochim Biophys Acta. 1973 Nov 15;327(1):46-56. doi: 10.1016/0005-2744(73)90102-2.
9
Steroid and non-steroid UDP glucuronyltransferase: glucuronidation of synthetic estrogens as steroids.类固醇和非类固醇尿苷二磷酸葡萄糖醛酸基转移酶：合成雌激素作为类固醇的葡萄糖醛酸化作用。
J Steroid Biochem. 1977 Aug;8(8):867-72. doi: 10.1016/0022-4731(77)90096-6.
10
Unconjugated bilirubin and an increased proportion of bilirubin monoconjugates in the bile of patients with Gilbert's syndrome and Crigler-Najjar disease.吉尔伯特综合征和克里格勒-纳贾尔病患者胆汁中存在未结合胆红素以及胆红素单结合物比例增加的情况。
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