Meberg A, Sande H, Foss O P, Stenwig J T
Acta Paediatr Scand. 1979 Jul;68(4):547-52. doi: 10.1111/j.1651-2227.1979.tb05053.x.
Twenty-eight mothers smoking 10--20 cigarettes daily during pregnancy had significantly higher serum thiocyanate concentrations at delivery compared in 25 non-smoking controls. The thiocyanate levels were positively correlated to cigarette consumption and inversely correlated to the birth weights of the infants. A highly significant correlation existed between serum thiocyanate levels of the mother and umbilical cord serum thiocyanate levels, reflecting a nearly complete equilibration. The thiocyanate concentrations in human milk on the 4th day after delivery were considerably lower than the serum concentrations, and no correlation existed between serum and milk concentrations. The infants of smoking mothers had significantly decreased weight and length at birth compared in infants of non-smokers. Birth weights were 3 344 +/- 434 g and 3 620 +/- 504 g respectively (p less than 0.05), and lengths 49.8 +/- 1.7 cm and 51 +/- 1.6 cm respectively (p less than 0.05). No differences were found between smokers and non-smokers in placental and umbilical cord histology, and umbilical cord artery medial area. It is concluded that serum thiocyanate concentration in smokers may be used as an objective measure for smoke exposure, and that maternal cigarette smoking acts as an exogenous factor which interferes with intrauterine development of the fetus in a dose related way.
28名在孕期每天吸烟10至20支的母亲，在分娩时血清硫氰酸盐浓度显著高于25名不吸烟的对照者。硫氰酸盐水平与香烟消耗量呈正相关，与婴儿出生体重呈负相关。母亲血清硫氰酸盐水平与脐带血清硫氰酸盐水平之间存在高度显著的相关性，这反映出两者几乎完全平衡。分娩后第4天母乳中的硫氰酸盐浓度明显低于血清浓度，且血清浓度与母乳浓度之间不存在相关性。与不吸烟母亲的婴儿相比，吸烟母亲的婴儿出生时体重和身长显著降低。出生体重分别为3344±434克和3620±504克（p<0.05），身长分别为49.8±1.7厘米和51±1.6厘米（p<0.05）。在胎盘和脐带组织学以及脐带动脉中膜面积方面，吸烟者与不吸烟者之间未发现差异。得出的结论是，吸烟者血清硫氰酸盐浓度可作为衡量烟雾暴露的客观指标，并且母亲吸烟作为一种外源性因素，以剂量相关的方式干扰胎儿的宫内发育。
