胶原蛋白细胞介导免疫反应的结构基础。小牛和大鼠胶原蛋白分离的α链在皮肤迟发型超敏反应中的反应性。
The structural basis of cell-mediated immunological reactions of collagen. Reactivity of separated -chains of calf and rat collagen in cutaneous delayed hypersensitivity reactions.
作者信息
Adelmann B C
出版信息
Immunology. 1972 Nov;23(5):739-48.
Denatured calf and rat skin collagen and α1- and α2-chains from these collagens were tested for their capacity to sensitize guinea-pigs for the cutaneous delayed hypersensitivity reaction and to elicit this reaction in sensitized animals. Alpha-chains from neutral salt extracted and from urea extracted collagen were also compared. All preparations were fully active as sensitizers as well as elicitors of the skin reaction. In spite of extensive cross-reactions, significant differences between α1- and α2-chains of a given species as well as between corresponding chains of different species could be detected. Differences between chains from neutral salt extracted collagen and from urea extracted collagen were also revealed.
对变性的小牛和大鼠皮肤胶原蛋白以及这些胶原蛋白的α1链和α2链进行了测试，以检测它们使豚鼠产生皮肤迟发型超敏反应的致敏能力，以及在致敏动物中引发该反应的能力。还比较了从中性盐提取的胶原蛋白和从尿素提取的胶原蛋白的α链。所有制剂作为皮肤反应的致敏剂和激发剂均具有充分活性。尽管存在广泛的交叉反应，但仍可检测到给定物种的α1链和α2链之间以及不同物种的相应链之间存在显著差异。还揭示了从中性盐提取的胶原蛋白链和从尿素提取的胶原蛋白链之间的差异。
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