嗜铬细胞瘤中多巴胺的分泌。
Secretion of dopa in phaeochromocytoma.
作者信息
Louis W J, Doyle A E, Heath W C, Robinson M J
出版信息
Br Med J. 1972 Nov 11;4(5836):325-7. doi: 10.1136/bmj.4.5836.325.
Abstract
In a series of 11 cases with phaeochromocytoma, two patients were found in whom the tumour secreted dopa in addition to dopamine, noradrenaline, and adrenaline. These two patients were normotensive in spite of high plasma and urinary levels of noradrenaline and adrenaline. This raises the possibility that dopa may be able to protect against the hypertensive action of noradrenaline. Such a mechanism would also explain the absence of hypertension in many cases of neuroblastoma.
摘要
在一系列11例嗜铬细胞瘤患者中，发现有两名患者的肿瘤除了分泌多巴胺、去甲肾上腺素和肾上腺素外，还分泌多巴。尽管这两名患者血浆和尿液中的去甲肾上腺素和肾上腺素水平很高，但他们的血压正常。这增加了多巴可能能够抵御去甲肾上腺素高血压作用的可能性。这样一种机制也可以解释许多神经母细胞瘤病例中高血压的缺失。
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引用本文的文献
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The role of epinephrine, norepinephrine, and dopamine in blood pressure disturbances in patients with pheochromocytoma.肾上腺素、去甲肾上腺素和多巴胺在嗜铬细胞瘤患者血压紊乱中的作用。
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本文引用的文献
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FORMATION OF TETRAHYDROPAPAVEROLINE FROM DOPAMINE IN VITRO.多巴胺在体外形成四氢罂粟碱。
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Hydroxytyramine and the adrenal medulla.羟酪胺与肾上腺髓质。
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Effect of L-dopa alone and in combination with an extracerebral decarboxylase inhibitor on blood pressure and some cardiovascular reflexes.左旋多巴单独及与脑外脱羧酶抑制剂联合应用对血压及某些心血管反射的影响。
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