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先前蛋白质餐对爱斯基摩人“糖尿病性”口服葡萄糖耐量的正常化作用。

Normalization effect of preceding protein meals on "diabetic" oral glucose tolerance in Eskimos.

作者信息

Schaefer O, Crockford P M, Romanowski B

出版信息

Can Med Assoc J. 1972 Oct 21;107(8):733-8.

Abstract

Routine testing of 76 clinically non-diabetic Eskimos showed marked impairment of oral glucose tolerance in 54% but normal intravenous glucose tolerance in most of these.Total insulin output following the glucose drink was not found different in Eskimos with normal and abnormal glucose tolerance nor did lean meat meals given 60 minutes before the glucose significantly increase it.Intolerance to oral glucose loads appeared significantly related to a delay of insulin release and both timing of insulin response and shape of blood glucose curve normalized in the meat-preceded tests.

摘要

对76名临床诊断非糖尿病的爱斯基摩人进行的常规检测显示,54%的人存在明显的口服葡萄糖耐量受损,但其中大多数人的静脉葡萄糖耐量正常。饮用葡萄糖后,葡萄糖耐量正常和异常的爱斯基摩人总的胰岛素分泌量并无差异,且在饮用葡萄糖前60分钟给予瘦肉餐也未显著增加胰岛素分泌量。对口服葡萄糖负荷的不耐受似乎与胰岛素释放延迟显著相关,并且在进食肉类后进行的测试中,胰岛素反应的时间和血糖曲线的形状均恢复正常。

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本文引用的文献

1
Diabetes among the Pima Indians of Arizona.
Ariz Med. 1961 Apr;18:99-106.
2
Diabetes mellitus in Eskimos.
Metabolism. 1957 Jul;6(4):320-5.
5
Stimulation of insulin secretion by amino acids.氨基酸对胰岛素分泌的刺激作用。
J Clin Invest. 1966 Sep;45(9):1487-502. doi: 10.1172/JCI105456.
7
Diabetes in the Cocopah Indians.
Diabetes. 1969 Jan;18(1):33-7. doi: 10.2337/diab.18.1.33.
8
Diabetes mellitus in Athabaskan Indians in Alaska.
Diabetes. 1969 Jan;18(1):29-32. doi: 10.2337/diab.18.1.29.

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