Lass J H, Pavan-Langston D, Park N H
Am J Ophthalmol. 1979 Jul;88(1):102-8. doi: 10.1016/0002-9394(79)90762-1.
Masked controlled rabbit studies were done to determine the toxic effects on corneal wound healing of the antiviral drugs 3% aciclovir and 0.5% idoxuridine ointment in therapeutically effective concentrations. Aciclovir had no significant detrimental effect in comparison to controls on the quality of regenerating epithelium or the re-epithelialization of epithelial wounds. Idoxuridine treatment caused significant toxic changes in the regenerating epithelium clinically and histologically with a significant delay in epithelial wound healing in comparison to control or aciclovir treated eyes. Aciclovir had no significant effect on the collagen content of stromal wounds as measured by hydroxyproline levels. Idoxuridine caused a reduction in collagen content not significantly different from controls but significantly lower than aciclovir.
进行了遮蔽对照兔研究，以确定治疗有效浓度的抗病毒药物3%阿昔洛韦和0.5%碘苷软膏对角膜伤口愈合的毒性作用。与对照组相比，阿昔洛韦对再生上皮的质量或上皮伤口的再上皮化没有显著的有害影响。与对照或阿昔洛韦治疗的眼睛相比，碘苷治疗在临床和组织学上导致再生上皮出现显著的毒性变化，上皮伤口愈合明显延迟。通过羟脯氨酸水平测量，阿昔洛韦对基质伤口的胶原蛋白含量没有显著影响。碘苷导致胶原蛋白含量降低，与对照组无显著差异，但明显低于阿昔洛韦组。
